Impact and Implications This work represents a rapid effort to inquire about the socio-emotional well-being of Chilean schoolers during extensive periods of quarantines due to the COVID-19 pandemic. The analysis considered how groups with different educational needs and SES have changed their well-being since 2018-2019 compared to 2020. This research calls attention to the need to respond with evidence-based data for those more affected. Results implicate that Chilean school-children have seen the most critical diminishing of their socio-emotional well-being during this time. Our results highlight the pressing need to provide parents and educators with tools to confront children's social and emotional development, especially for the more vulnerable populations.