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| DOI | 10.1016/J.NEUROPSYCHOLOGIA.2013.01.008 | ||||
| Año | 2013 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Recently (Roca et al. (2010), we used the relationship with general intelligence (Spearman's g) to define two sets of frontal lobe or "executive" tests. For one group, including Wisconsin card sorting and verbal fluency, reduction in g entirely explained the deficits found in frontal patients. For another group, including tests of social cognition and multitasking, frontal deficits remained even after correction for g. Preliminary evidence suggested a link of the latter tasks to more anterior frontal regions. Here we develop this distinction in the context of behavioural-variant frontotemporal dementia (bvFTD), a disorder which progressively affects frontal lobe cortices. In bvFTD, some executive tests, including tests of social cognition and multitasking, decline from the early stage of the disease, while others, including classical executive tests such as Wisconsin card sorting, verbal fluency or Trail Making Test part B, show deficits only later on. Here we show that, while deficits in the classical executive tests are entirely explained by g, deficits in the social cognition and multitasking tests are not. The results suggest a relatively selective cognitive deficit at mild stages of the disease, followed by more widespread cognitive decline well predicted by g. (C) 2013 Elsevier Ltd. All rights reserved.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Roca, Maria | Mujer |
Inst Cognit Neurol INECO - Argentina
Universidad Favaloro - Argentina Instituto de Neurología Cognitiva, Buenos Aires - Argentina |
| 2 | MANES, FACUNDO FRANCISCO | Hombre |
Inst Cognit Neurol INECO - Argentina
Universidad Favaloro - Argentina Instituto de Neurología Cognitiva, Buenos Aires - Argentina |
| 3 | Gleichgerrcht, E. | Hombre |
Inst Cognit Neurol INECO - Argentina
Universidad Favaloro - Argentina Instituto de Neurología Cognitiva, Buenos Aires - Argentina |
| 4 | Watson, Peter | Hombre |
MRC Cognit & Brain Sci Unit - Reino Unido
MRC Cognition and Brain Sciences Unit - Reino Unido |
| 5 | LEGAZ, AGUSTINA | Mujer |
Inst Cognit Neurol INECO - Argentina
Universidad Diego Portales - Chile Instituto de Neurología Cognitiva, Buenos Aires - Argentina |
| 6 | Thompson, Russell | Hombre |
MRC Cognit & Brain Sci Unit - Reino Unido
MRC Cognition and Brain Sciences Unit - Reino Unido |
| 7 | Acosta, Daisy M. | Mujer |
Inst Cognit Neurol INECO - Argentina
Universidad Favaloro - Argentina |
| 8 | Duncan, J. | Hombre |
MRC Cognit & Brain Sci Unit - Reino Unido
MRC Cognition and Brain Sciences Unit - Reino Unido |
| Fuente |
|---|
| FONDECYT |
| Consejo Nacional de Investigaciones Científicas y Técnicas |
| CONICET |
| Fondo Nacional de Desarrollo Científico y Tecnológico |
| Medical Research Council |
| INECO Foundation |
| Fondo Nacional de Desarrollo CientÃfico, Tecnológico y de Innovación Tecnológica |
| Consejo Nacional de Investigaciones CientÃficas y Técnicas |
| Medical Research Council (UK) |
| Fundacion INECO |
| Agradecimiento |
|---|
| This work was supported by Medical Research Council (UK) intramural program MC-A060-5PQ10 and by grants FONDECYT (1130920), CONICET and INECO Foundation. |
| This work was supported by Medical Research Council (UK) intramural program MC-A060-5PQ10 and by grants FONDECYT ( 1130920 ), CONICET and INECO Foundation. |