This paper offers our view of memory as relational process, a view derived both from Emmanuel Ghent's systems understanding of relational and from Gerald Edelman's biological understanding of process. Memory in our view is understood as relational rather than self-referenced and self-bound; as ongoing process rather than as static representation; as creation rather than as replication; as idiosyncratic in the moment rather than as faithful to the past; and as fluid rather than as fixed, although, as we stress, at times it in fact may feel so different, so fixed, and so faithful to the past. The defining attributes that we conceptualize offer a biological understanding of memory as it actually forms in the brain, emerging from dynamic neuronal patterns and the protein codes by which these variable patterns are set into motion. Generalizations derived from Edelman's global brain theory provide the clinician with both nomothetic and idiographic understanding of memory and its emergence in human experience. Specifically, three such nomothetic generalizations are described and then applied to case material, illustrating the importance of this biological brain-based conceptualization of memory to a more complex understanding of our patients.