In this paper we study the analytical obstructions preventing the germ of a generic analytic family of elliptic ordinary differential equations from being isochronous. The formal obstructions are purely arithmetical and can be set in terms of commutators. The analytical obstructions arise out of the non-convergence of the normalizing coordinates in the Poincare-Dulac normalization process. The temporal part of the invariant is the obstruction to isochronicity in a particular context.