Background: Oral and Maxillofacial injuries are an important problem at public health services, due to the anatomical complexity of the involved areas and committed aesthetic factor. Aim: To determine and analyze the etiology, frequency, location and treatment of patients with maxillofacial trauma at a Chilean regional Hospital between 2004 and 2011. Material and Methods: Review of medical records of 343 patients aged 0 to 87 years (258 males) treated for maxillofacial trauma. Results: Physical aggression was the main etiologic factor in 35% of patients, followed by falls and sports injuries in 27 and 16% of cases respectively. The most commonly damaged structure was the dentoalveolar area in 43% of patients, followed by mandibular and malar lesions in 31 and 12% of cases. Twenty two percent of patients required an open reduction with osteosynthesis as treatment. Discussion: Maxillofacial trauma was more common in males. The main etiologic factor was physical aggression and the most affected damaged structure was the dentoalveolar area. Osteosynthesis was required for treatment in 22% of cases.