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| DOI | 10.1093/BIOINFORMATICS/BTT597 | ||||
| Año | 2014 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Results: We present a method that enables to organize the data from any metabolomics experiment into metabolic stories. Each story corresponds to a possible scenario explaining the flow of matter between the metabolites of interest. These scenarios may then be ranked in different ways depending on which interpretation one wishes to emphasize for the causal link between two affected metabolites: enzyme activation, enzyme inhibition or domino effect on the concentration changes of substrates and products. Equally probable stories under any selected ranking scheme can be further grouped into a single anthology that summarizes, in a unique subnetwork, all equivalently plausible alternative stories. An anthology is simply a union of such stories. We detail an application of the method to the response of yeast to cadmium exposure. We use this system as a proof of concept for our method, and we show that we are able to find a story that reproduces very well the current knowledge about the yeast response to cadmium. We further show that this response is mostly based on enzyme activation. We also provide a framework for exploring the alternative pathways or side effects this local response is expected to have in the rest of the network. We discuss several interpretations for the changes we see, and we suggest hypotheses that could in principle be experimentally tested. Noticeably, our method requires simple input data and could be used in a wide variety of applications.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | ACUNA-AGUAYO, VICENTE ERNESTO | Hombre |
Inria Grenoble Rhone Alpes - Francia
Univ Lyon - Francia UNIV LYON 1 - Francia CNRS - Francia LNCC - Brasil Universidad de Chile - Chile Univ Evry - Francia Vrije Univ Amsterdam - Países Bajos CWI - Países Bajos Université de Lyon - Francia Université Claude Bernard Lyon 1 - Francia Laborató Rio Nacional de Computaç Ão Cientý́fica (LNCC) - Brasil Laboratoire de Mathématiques et Modélisation d'Évry - Francia Vrije Universiteit Amsterdam - Países Bajos |
| 2 | ACUNA-AGUAYO, VICENTE ERNESTO | Hombre |
Inria Grenoble Rhone Alpes - Francia
Univ Lyon - Francia UNIV LYON 1 - Francia CNRS - Francia LNCC - Brasil Universidad de Chile - Chile Univ Evry - Francia Vrije Univ Amsterdam - Países Bajos CWI - Países Bajos Université de Lyon - Francia Université Claude Bernard Lyon 1 - Francia Laborató Rio Nacional de Computaç Ão Cientý́fica (LNCC) - Brasil Laboratoire de Mathématiques et Modélisation d'Évry - Francia Vrije Universiteit Amsterdam - Países Bajos |
| 3 | Cottret, Ludovic | Hombre |
UMR CNRS 5504 INRA 792 - Francia
Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés - (LISBP) - Francia TBI -Toulouse Biotechnology Institute Bio & Chemical Engineering - Francia |
| 4 | ACUNA-AGUAYO, VICENTE ERNESTO | Hombre |
Inria Grenoble Rhone Alpes - Francia
Univ Lyon - Francia UNIV LYON 1 - Francia CNRS - Francia LNCC - Brasil Universidad de Chile - Chile Univ Evry - Francia Vrije Univ Amsterdam - Países Bajos CWI - Países Bajos Université de Lyon - Francia Université Claude Bernard Lyon 1 - Francia Laborató Rio Nacional de Computaç Ão Cientý́fica (LNCC) - Brasil Laboratoire de Mathématiques et Modélisation d'Évry - Francia Vrije Universiteit Amsterdam - Países Bajos |
| 5 | ACUNA-AGUAYO, VICENTE ERNESTO | Hombre |
Inria Grenoble Rhone Alpes - Francia
Univ Lyon - Francia UNIV LYON 1 - Francia CNRS - Francia LNCC - Brasil Universidad de Chile - Chile Univ Evry - Francia Vrije Univ Amsterdam - Países Bajos CWI - Países Bajos Université de Lyon - Francia Université Claude Bernard Lyon 1 - Francia Laborató Rio Nacional de Computaç Ão Cientý́fica (LNCC) - Brasil Laboratoire de Mathématiques et Modélisation d'Évry - Francia Vrije Universiteit Amsterdam - Países Bajos |
| 6 | Borassi, Michele | Mujer |
Scuola Normale Super Pisa - Italia
Scuola Normale Superiore di Pisa - Italia |
| 7 | Junot, Christophe | Hombre |
CEA Saclay - Francia
Institut de Biologie et de Technologies de Saclay - Francia |
| 8 | Marchetti-Spaccamela, Alberto | Hombre |
Univ Roma La Sapienza - Italia
Università degli Studi di Roma La Sapienza - Italia Sapienza Università di Roma - Italia |
| 9 | Marino, Andrea | Mujer |
UNIV FLORENCE - Italia
Università degli Studi di Firenze - Italia |
| 10 | ACUNA-AGUAYO, VICENTE ERNESTO | Hombre |
Inria Grenoble Rhone Alpes - Francia
Univ Lyon - Francia UNIV LYON 1 - Francia CNRS - Francia LNCC - Brasil Universidad de Chile - Chile Univ Evry - Francia Vrije Univ Amsterdam - Países Bajos CWI - Países Bajos Université de Lyon - Francia Université Claude Bernard Lyon 1 - Francia Laborató Rio Nacional de Computaç Ão Cientý́fica (LNCC) - Brasil Laboratoire de Mathématiques et Modélisation d'Évry - Francia Vrije Universiteit Amsterdam - Países Bajos |
| 11 | Jourdan, Fabien | Hombre |
INRA - Francia
Toxicologie Alimentaire - (ToxAlim) - Francia |
| 12 | Crescenzi, Pierluigi | Hombre |
UNIV FLORENCE - Italia
Università degli Studi di Firenze - Italia |
| 13 | ACUNA-AGUAYO, VICENTE ERNESTO | Hombre |
Inria Grenoble Rhone Alpes - Francia
Univ Lyon - Francia UNIV LYON 1 - Francia CNRS - Francia LNCC - Brasil Universidad de Chile - Chile Univ Evry - Francia Vrije Univ Amsterdam - Países Bajos CWI - Países Bajos Université de Lyon - Francia Université Claude Bernard Lyon 1 - Francia Laborató Rio Nacional de Computaç Ão Cientý́fica (LNCC) - Brasil Laboratoire de Mathématiques et Modélisation d'Évry - Francia Vrije Universiteit Amsterdam - Países Bajos |
| 13 | Lacroix, Vincent | Hombre |
Inria Grenoble Rhone Alpes - Francia
Univ Lyon - Francia UNIV LYON 1 - Francia CNRS - Francia Université de Lyon - Francia Université Claude Bernard Lyon 1 - Francia |
| 14 | Sagot, Marie France | Mujer |
Inria Grenoble Rhone Alpes - Francia
Univ Lyon - Francia UNIV LYON 1 - Francia CNRS - Francia Université de Lyon - Francia Université Claude Bernard Lyon 1 - Francia |
| Fuente |
|---|
| European Research Council |
| FP7/2007 |
| Seventh Framework Programme |
| European Research Council (ERC) |
| European Research Council under the European Community |
| ANR |
| CIRIC-INRIA |
| French project |
| NWO-CLS MEMESA project |
| 'DISCO' PRIN National Research Project |
| Plateforme Bioinformatique de Toulouse |
| CIRIC-INRIA Chile line Natural Resources |
| ANR-BBSRC Systryp |
| LabEx ECOFECT |
| NWO-CLS |
| Agradecimiento |
|---|
| European Research Council under the European Community's Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no. (247073)10; the French project (ANR MIRI BLAN08-1335497); and the ANR funded LabEx ECOFECT. It was partially supported by the Plateforme Bioinformatique de Toulouse, ANR-BBSRC Systryp, the CIRIC-INRIA Chile line Natural Resources, the NWO-CLS MEMESA project and the 'DISCO' PRIN National Research Project. |
| Funding: European Research Council under the European Community’s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no. (247073)10; the French project (ANR MIRI BLAN08-1335497); and the ANR funded LabEx ECOFECT. It was partially supported by the Plateforme Bioinformatique de Toulouse, ANR-BBSRC Systryp, the CIRIC-INRIA Chile line Natural Resources, the NWO-CLS MEMESA project and the ‘DISCO’ PRIN National Research Project. |