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Age-dependent association among Helicobacter pylori infection, serum pepsinogen levels and immune response of children to live oral cholera vaccine CVD 103-HgR
| Indexado |
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| DOI | 10.1371/JOURNAL.PONE.0083999 | ||||
| Año | 2014 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
Conclusions: As H. pylori gastritis progresses with increasing pediatric age in developing country venues, changes in gastric secretion ensue that we believe explain the observed differences in age-related immune responses to immunization with live oral cholera vaccine. The effect of H. pylori and changes of gastric acid secretion on the immunogenicity of various oral vaccines should be studied in different developing, transitional and industrialized country settings.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Muhsen, Khitam | - |
UNIV MARYLAND - Estados Unidos
University of Maryland, Baltimore - Estados Unidos Tel Aviv University, Sackler Faculty of Medicine - Israel University of Maryland, Baltimore (UMB) - Estados Unidos Tel Aviv University - Israel |
| 2 | Lagos, Rosanna | Mujer |
Hospital de Niños Dr Roberto del Rio - Chile
Hospital de Niños Robeto del Rio - Chile Hospital de Niños Roberto del Río - Chile Hosp Ninos Roberto del Rio - Chile |
| 3 | Reymann, Mardi K. | - |
UNIV MARYLAND - Estados Unidos
University of Maryland, Baltimore - Estados Unidos University of Maryland, Baltimore (UMB) - Estados Unidos |
| 4 | Graham, David Y. | Hombre |
BAYLOR COLL MED - Estados Unidos
Baylor College of Medicine - Estados Unidos |
| 5 | Pasetti, Marcela F. | Mujer |
UNIV MARYLAND - Estados Unidos
University of Maryland, Baltimore - Estados Unidos University of Maryland, Baltimore (UMB) - Estados Unidos |
| 6 | Levine, Myron M. | Hombre |
UNIV MARYLAND - Estados Unidos
University of Maryland, Baltimore - Estados Unidos University of Maryland, Baltimore (UMB) - Estados Unidos |
| Fuente |
|---|
| NIH |
| World Health Organization |
| National Institute of Allergy and Infectious Diseases |
| Center for Vaccine Development, University of Maryland School of Medicine |
| Agradecimiento |
|---|
| This work was supported by a grant from the World Health Organization; NIH cooperative research agreements (AI-35948 and UO1AI35948) and research contracts (AI-45251 and NO1 AI 15096) between the National Institute of Allergy and Infectious Diseases and Center for Vaccine Development, University of Maryland School of Medicine. The funding sources did not have any role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. None of the authors have financial conflicts of interest with respect to the subject of this research. Prof. M. Levine is the co-holder of patents but at present CVD 103-HgR is not available commercially. However, PaxVax, a vaccine manufacturer in San Diego, CA, has initiated a clinical development program to re-commercialize CVD 103-HgR (as VibrioVaxH) and return it to market as a licensed vaccine within the next few years. |
