We present a detailed record from Lago Lepue to examine vegetation, climate and fire-regime changes since the Last Glacial Maximum (LGM) in central-east Isla Grande de Chiloe (43 S), northwestern Patagonia. Precipitation in this region correlates with the intensity of the southern westerly winds (SWW), allowing reconstruction of past SWW behavior through precipitation-sensitive sensors. Recession from the LGM glacier margins exposed the central-east sector of Isla Grande de Chiloe by 17,800 cal yr BP, followed by the immediate colonization of pioneer cold-resistant herbs/shrubs and rapid establishment of closed-canopy Nothofagus forests by 17,000 cal yr BP. Broad-leaved temperate rainforests have persisted since then with compositional changes driven by changes in temperature, hydrologic balance and disturbance regimes. We detect low lake levels and enhanced fire activity between 800-2000, 4000-4300, ,000 and 16,100-17,800 cal yr BP, implying southward shifts and/or weaker SVVW flow that alternated with cold, humid phases with muted fire activity. Covariation in paleoclimate trends revealed by the Lago Lepue record with tropical and Antarctic records since the LGM, suggests that the SWW have been a highly dynamic component of the climate system capable of linking climate changes from low- and high-southern latitudes during the Last Glacial termination and the current interglacial. (C) 2014 Elsevier Ltd.. All rights reserved.