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Intasome architecture and chromatin density modulate retroviral integration into nucleosome
| Indexado |
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| DOI | 10.1186/S12977-015-0145-9 | ||||
| Año | 2015 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
Conclusions: Thus, both intasome architecture and compactness of the chromatin surrounding the targeted nucleosome appear important determinants of the retroviral integration site selectivity. This supports a mechanism involving a global targeting of the intasomes toward suitable chromatin regions followed by a local integration site selection modulated by the intrinsic structural constraints of the intasomes governing the target DNA bending and dictating their sensitivity toward suitable specific nucleosomal structures and density.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Benleulmi, Mohamed Salah | Hombre |
Univ Bordeaux - Francia
Université de Bordeaux - Francia |
| 1 | Benleulmi, Salah S. | Hombre |
Université de Bordeaux - Francia
|
| 2 | Matysiak, Julien | Hombre |
Univ Bordeaux - Francia
Université de Bordeaux - Francia |
| 3 | HENRIQUEZ-GALLARDO, DANIEL RODRIGO | Hombre |
Universidad de Chile - Chile
|
| 3 | Henriquez, Rodrigo R. | Hombre |
Universidad de Chile - Chile
|
| 4 | Vaillant, Cedric | Hombre |
Ecole Normale Super Lyon - Francia
Ecole Normale Supérieure de Lyon - Francia CNRS Centre National de la Recherche Scientifique - Francia |
| 5 | Lesbats, Paul | Hombre |
Univ Bordeaux - Francia
Université de Bordeaux - Francia Cancer Research UK - Reino Unido |
| 6 | Calmels, Christina | Mujer |
Univ Bordeaux - Francia
Université de Bordeaux - Francia |
| 7 | Naughtin, Monica | Mujer |
Ecole Normale Super Lyon - Francia
Laboratoire Joliot Curie - Francia CNRS Centre National de la Recherche Scientifique - Francia Ecole Normale Supérieure de Lyon - Francia Institut Cochin - Francia |
| 8 | LEON-DECAP, OSCAR ENRIQUE | Hombre |
Universidad de Chile - Chile
|
| 9 | Skalka, Anna Marie | Mujer |
Fox Chase Canc Ctr - Estados Unidos
Fox Chase Cancer Center - Estados Unidos |
| 10 | Ruff, Marc | Hombre |
UDS - Francia
IGBMC Institut de Genetique et de Biologie Moleculaire et Cellulaire - Francia CNRS Centre National de la Recherche Scientifique - Francia |
| 11 | Lavigne, Marc | Hombre |
Ecole Normale Super Lyon - Francia
INST PASTEUR - Francia Ecole Normale Supérieure de Lyon - Francia Institut Pasteur, Paris - Francia CNRS Centre National de la Recherche Scientifique - Francia |
| 12 | Andreola, Marie-Line | Mujer |
Univ Bordeaux - Francia
Université de Bordeaux - Francia |
| 13 | Parissi, Vincent | Hombre |
Univ Bordeaux - Francia
Université de Bordeaux - Francia |
| Fuente |
|---|
| ECOS-CONICYT |
| Agence Nationale de la Recherche |
| National Institute of Allergy and Infectious Diseases |
| Centre National de la Recherche Scientifique |
| Centre National de la Recherche Scientifique (CNRS) |
| University Victor Segalen Bordeaux 2 |
| French National Research Agency against AIDS (ANRS) |
| French Research Group |
| French National Research Agency (ANR, RETROSelect program) |
| Agradecimiento |
|---|
| The work was supported by the French National Research Agency (ANR, RETROSelect program), the French National Research Agency against AIDS (ANRS), the Centre National de la Recherche Scientifique (CNRS), the University Victor Segalen Bordeaux 2, the French Research Group GDR 3546 "Les Elements Genetiques Mobiles : du mecanisme aux populations, une approche integrative", and the ECOS-CONICYT C12B03 program. The authors are deeply grateful to Dr Simon Litvak for fruitful discussions and constant encouragement and to Prof. R. Cooke (University Victor Segalen Bordeaux 2) for proofreading the manuscript. |
| The work was supported by the French National Research Agency (ANR, RETROSelect program), the French National Research Agency against AIDS (ANRS), the Centre National de la Recherche Scientifique (CNRS), the University Victor Segalen Bordeaux 2, the French Research Group GDR 3546 “Les Eléments Génétiques Mobiles : du mécanisme aux populations, une approche integrative”, and the ECOS-CONICYT C12B03 program. The authors are deeply grateful to Dr Simon Litvak for fruitful discussions and constant encouragement and to Prof. R. Cooke (University Victor Segalen Bordeaux 2) for proofreading the manuscript. |
