We present a digital fixed-point architecture that performs real-time nonuniformity correction in infrared (IR) focal plane arrays using the Constant Range algorithm. The circuit estimates and compensates online the gains and offsets of a first-order nonuniformity model using pixel statistics from the video stream. We demonstrate our architecture with a prototype built on a Xilinx Spartan-6 XC6SLX45T field-programmable gate array (FPGA), which can process an IR video stream from a FUR Tau 2 long-wave IR camera with a resolution of 640 x 480 14-bit pixels at up to 238 frames per second (fps) with low resource utilization and adds only 13 mW to the FPGA power. Post-layout simulations of a custom integrated circuit implementation of the architecture on a 32 nm CMOS process show that the circuit can operate at up to 900 fps at the same resolution, and consume less than 4.5 mW. (C) 2015 Elsevier B.V. All rights reserved.