The data presented in this article are related to the research article entitled "Solar domestic hot water regulation in the Latin American residential sector with the implementation of the Energy Performance of Buildings Directive: The case of Chile" (Lopez-Ochoa et al., 2019), which evaluates the possibility of adapting Spanish solar domestic hot water regulations in Chile, with the objective of presenting the potential impact of the Energy Performance of Buildings Directive in Latin America. This dataset was made publicly available to show the possible energy savings with the thermal solar systems proposed to enable the use of these data by other researchers as well as designers, installers and decision-makers. (c) 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).