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A controlled study of tuberculosis diagnosis in HIV-infected and uninfected children in Peru
| Indexado |
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| DOI | 10.1371/JOURNAL.PONE.0120915 | ||||
| Año | 2015 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
In HIV-positive children with suspected tuberculosis, diagnostic yield was so low that 1458 microscopy and culture tests were done per case confirmed and even in children with culture-proven tuberculosis most tests and specimens were false-negative; whereas PCR was so prone to false-positives that PCR-positivity was as likely in specimens from well-controls as suspected-tuberculosis cases. This demonstrates the importance of control participants in diagnostic test evaluation and that even extensive laboratory testing only rarely contributed to the care of children with suspected TB.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Oberhelman, Richard A. | Hombre |
Tulane Sch Publ Hlth & Trop Med - Estados Unidos
Tulane University School of Public Health and Tropical Medicine - Estados Unidos |
| 2 | Soto-Castellares, Giselle | Mujer |
Asociac Benef Proyectos Informat Salud Med & Agr - Perú
US Naval Med Res Unit Six - Perú Asociacion Benefica PRISMA Lima - Perú Naval Medical Research Unit No. 6 - Perú |
| 3 | Gilman, Robert H. | Hombre |
Asociac Benef Proyectos Informat Salud Med & Agr - Perú
UNIV PERUANA CAYETANO HEREDIA - Perú Johns Hopkins Bloomberg Sch Publ Hlth - Estados Unidos Asociacion Benefica PRISMA Lima - Perú Universidad Peruana Cayetano Heredia - Perú Johns Hopkins Bloomberg School of Public Health - Estados Unidos |
| 4 | Castillo, María E. | Mujer |
Inst Nacl Salud Nino - Perú
UNIV PERUANA CAYETANO HEREDIA - Perú Instituto Nacional de Salud del Nino, Lima - Perú Universidad Peruana Cayetano Heredia - Perú |
| 5 | Kolevic, Lenka | Mujer |
Inst Nacl Salud Nino - Perú
Instituto Nacional de Salud del Nino, Lima - Perú |
| 6 | Delpino, Trinidad | Mujer |
Inst Nacl Salud Nino - Perú
Instituto Nacional de Salud del Nino, Lima - Perú |
| 7 | Saito, Mayuko | Mujer |
Asociac Benef Proyectos Informat Salud Med & Agr - Perú
Asociacion Benefica PRISMA Lima - Perú Universidad Peruana Cayetano Heredia - Perú Tohoku University School of Medicine - Japón Graduate School of Medicine - Japón |
| 8 | Salazar-Lindo, Eduardo | Hombre |
Hosp Nacl Cayetano Heredia - Perú
Hospital Nacional Cayetano Heredia - Perú |
| 9 | Negron, Eduardo | Hombre |
Hosp Nacl Cayetano Heredia - Perú
Hospital Nacional Cayetano Heredia - Perú |
| 10 | MONTENEGRO-HEREDIA, SONIA | Mujer |
Universidad de Concepción - Chile
|
| 11 | LAGUNA-TORRES, VICTOR ALBERTO | Hombre |
US Naval Med Res Unit Six - Perú
|
| 11 | Laguna-Torres, V. Alberto | - |
Naval Medical Research Unit No. 6 - Perú
US Naval Med Res Unit Six - Perú |
| 12 | Maurtua-Neumann, Paola | Mujer |
TULANE UNIV - Estados Unidos
Tulane University School of Medicine - Estados Unidos University of South Alabama - Estados Unidos |
| 13 | Datta, Sumona | - |
UNIV PERUANA CAYETANO HEREDIA - Perú
Univ London Imperial Coll Sci Technol & Med - Reino Unido IFHAD Innovat Hlth & Dev - Reino Unido Universidad Peruana Cayetano Heredia - Perú Wellcome Trust - Reino Unido IFHAD: Innovation For Health And Development - Reino Unido |
| 14 | Evans, Carlton A. | Hombre |
UNIV PERUANA CAYETANO HEREDIA - Perú
Univ London Imperial Coll Sci Technol & Med - Reino Unido IFHAD Innovat Hlth & Dev - Reino Unido Universidad Peruana Cayetano Heredia - Perú Wellcome Trust - Reino Unido IFHAD: Innovation For Health And Development - Reino Unido |
| Fuente |
|---|
| Fogarty International Center |
| National Institutes of Health |
| United States Agency for International Development |
| Wellcome Trust |
| NIAID |
| National Institute of Allergy and Infectious Diseases |
| U.S. Department of Defense |
| NIHR Imperial Biomedical Research Centre |
| U.S. government |
| United States Government |
| Department for International Development, UK government |
| USAID TB |
| IFHAD: Innovation For Health And Development |
| Joint Global Health Trials consortium (Wellcome Trust/MRC/DFID) |
| Imperial College Biomedical Research Centre |
| Bill & Melinda Gates Foundation - Grand Challenges Explorations Initiative |
| Fogarty-NIH AIDS training program |
| NIH ITREID |
| Innovation For Health And Development |
| U.S.C. |
| Wellcome Trust/MRC/DFID |
| NIAID tutorial |
| Global Health Trials |
| Virginia Marine Resources Commission |
| Agradecimiento |
|---|
| This research study was supported entirely by National Institutes of Health grant 1 RO1 AI-49139. Collaborators and the diagnostic laboratory for this research were also funded by: USAID TB Award HRN-5986-A-00-6006-00; NIH ITREID grant 5D43-TW00910; Fogarty-NIH AIDS training program 3T22-TW00016-05S3; NIAID tutorial training grant 5T35-AI07646-02; IFHAD: Innovation For Health And Development; Joint Global Health Trials consortium (Wellcome Trust/MRC/DFID); The Wellcome Trust; and Imperial College Biomedical Research Centre. NAMRU-6 work was supported by Work Unit Number 62787 S17 H B0002. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| This research study was supported entirely by National Institutes of Health grant 1 RO1 AI- 49139. Collaborators and the diagnostic laboratory for this research were also funded by: USAID TB Award HRN-5986-A-00-6006-00; NIH ITREID grant 5D43- TW00910; Fogarty-NIH AIDS training program 3T22- TW00016-05S3; NIAID tutorial training grant 5T35- AI07646-02; IFHAD: Innovation For Health And Development; Joint Global Health Trials consortium (Wellcome Trust/MRC/DFID); The Wellcome Trust; and Imperial College Biomedical Research Centre. NAMRU-6 work was supported by Work Unit Number 62787 S17 H B0002. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. In memoriam Luz Caviedes, who led the laboratory aspects of this research project with great enthusiasm, skill and dedication. We thank Dr. David A. J. Moore for his advice and encouragement, and we thank the participants, their families and the personnel of the regional and national health systems in Peru for supporting this research. Disclaimer: The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U.S. Government. Copyright Statement: V. Alberto Laguna-Torres and Giselle Soto-Castellares are employees of the U.S. Government. This work was prepared as part of their official duties. Title 17 U.S.C. § 105 provides that ''Copyright protection under this title is not available for any work of the United States Government''. Title 17 U.S.C. § 101. |
