Archaeological sites composed only of surficial lithics are widespread in arid environments. Numerical dating of such sites is challenging, however, and even establishing a relative chronology can be daunting. One potentially helpful method for assigning relative chronologies is to use lithic weathering, on the assumption that the most weathered artifacts are also the oldest. Yet, few studies have systematically assessed how local environmental processes affect weathering of surficial lithics. Using macroscopic analyses, we compared the weathering of surficial lithic assemblages from seven mid-to-late Holocene archaeological sites sampled from four different microenvironments in the Atacama Desert of northern Chile. Changes in polish, texture, shine, and color were used to establish significant differences in weathering between two kinds of locations: interfluves and canyon sites. Lithics from interfluve sites were moderately to highly weathered by wind and possessed a dark coating, whereas canyon lithics were mildly weathered despite greater exposure to moisture, often lacked indications of eolian abrasion, and lacked dark coatings. Our results show that lithic weathering can be used as a proxy for relative age, but only after considering local environmental factors. The power of such chronologies can be improved by combining archaeological, paleoenvironmental, geomorphological, and taphonomic data.