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Endoplasmic Reticulum Stress-Activated Cell Reprogramming in Oncogenesis
| Indexado |
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| DOI | 10.1158/2159-8290.CD-14-1490 | ||||
| Año | 2015 | ||||
| Tipo | revisión |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
Significance: ER stress signaling is dysregulated in many forms of cancer and contributes to tumor growth as a survival factor, in addition to modulating other disease-associated processes, including cell migration, cell transformation, and angiogenesis. Evidence for targeting the ER stress signaling pathway as an anticancer strategy is compelling, and novel agents that selectively inhibit the UPR have demonstrated preliminary evidence of preclinical efficacy with an acceptable safety profile. (C) 2015 AACR.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Chevet, Eric | Hombre |
Univ Rennes - Francia
Ctr Lutte Canc Eugene Marquis - Francia University of Rennes - Francia Centre de Lutte Contre le Cancer Eugène Marquis - Francia |
| 2 | HETZ-FLORES, CLAUDIO ANDRES | Hombre |
Universidad de Chile - Chile
Ctr Mol Studies Cell - Chile Harvard University - Estados Unidos Center for Molecular Studies of the Cell - Chile Harvard T.H. Chan School of Public Health - Estados Unidos |
| 3 | Samali, Afshin | Hombre |
Natl Univ Ireland Galway - Irlanda
National University of Ireland Galway - Irlanda University of Galway - Irlanda |
| Fuente |
|---|
| FONDECYT |
| Fondef |
| Fondo de Fomento al Desarrollo Científico y Tecnológico |
| ECOS-CONICYT |
| Millennium Institute |
| Fundacion Copec-UC |
| Copec-UC foundation |
| Ligue contre le Cancer |
| Fondo de Fomento al Desarrollo CientÃfico y Tecnológico |
| Michael J. Fox Foundation for Parkinson's Research |
| Institut National du Cancer (INCA) |
| Institut National Du Cancer |
| Ring Initiative |
| Frick Foundation |
| Fundación Copec-UC |
| Breast Cancer Campaign |
| Irish Cancer Society |
| Ligue Nationale Contre le Cancer (Comites des Landes) |
| Belgian grants-Interuniversity Attraction Poles |
| FONDECYTno |
| Belgian grants—Interuniversity Attraction Poles |
| Cancer Campaign |
| Agradecimiento |
|---|
| The authors' work has been funded by grants from Institut National du Cancer (INCa) and Ligue Nationale Contre le Cancer (Comites des Landes) to E. Chevet; a French-Chilean program exchange grant from ECOS-CONICYT C13S02 to E. Chevet and C. Hetz; and FONDECYT no. 1140549, Millennium Institute no. P09-015-F, and Ring Initiative ACT1109 grants, CONICYT-USA2013-0003, the Michael J. Fox Foundation for Parkinson's Research, the COPEC-UC Foundation, FONDEF no. D11I1007, and the Frick Foundation, to C. Hetz. The research in the A. Samali laboratory is supported by the Irish Cancer Society (CRS11CLE), the Breast Cancer Campaign (2010NOVPR13), and the Belgian grants-Interuniversity Attraction Poles, IAP 7/32. |
| The authors’ work has been funded by grants from Institut National du Cancer (INCa) and Ligue Nationale Contre le Cancer (Comités des Landes) to E. Chevet; a French–Chilean program exchange grant from ECOS-CONICYT C13S02 to E. Chevet and C. Hetz; and FONDECYTno. 1140549, Millennium Institute no. P09-015-F, and Ring Initiative ACT1109 grants, CONICYT-USA2013-0003, the Michael J. Fox Foundation for Parkinson’s Research, the COPEC-UC Foundation, FONDEF no. D11I1007, and the Frick Foundation, to C. Hetz. The research in the A. Samali laboratory is supported by the Irish Cancer Society (CRS11CLE), theBreast Cancer Campaign (2010NOVPR13), and the Belgian grants—Interuniversity Attraction Poles, IAP 7/32. |
