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Statin Use and Adrenal Aldosterone Production in Hypertensive and Diabetic Subjects
| Indexado |
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| DOI | 10.1161/CIRCULATIONAHA.115.016759 | ||||
| Año | 2015 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
Conclusions-Statin use among hypertensive and diabetic subjects was associated with lower aldosterone secretion in response to angiotensin II and a low-sodium diet in 2 human intervention studies. This effect appeared to be most pronounced with lipophilic statins and higher doses. Future studies to evaluate whether aldosterone inhibition may partially explain the robust cardioprotective effects of statins are warranted.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | BAUDRAND-BIGGS, RENE FELIPE | Hombre |
Harvard University - Estados Unidos
Pontificia Universidad Católica de Chile - Chile Brigham and Women's Hospital - Estados Unidos Harvard Medical School - Estados Unidos |
| 2 | Pojoga, Luminita H. | - |
Harvard University - Estados Unidos
Brigham and Women's Hospital - Estados Unidos Harvard Medical School - Estados Unidos |
| 3 | Vaidya, Anand | Hombre |
Harvard University - Estados Unidos
Brigham and Women's Hospital - Estados Unidos Harvard Medical School - Estados Unidos |
| 4 | Garza, Amanda | Mujer |
Harvard University - Estados Unidos
Brigham and Women's Hospital - Estados Unidos Harvard Medical School - Estados Unidos |
| 5 | VOHRINGER-CARDENAS, PAUL ALFRED | Hombre |
Universidad de Chile - Chile
Tufts Univ - Estados Unidos Hospital Clínico de la Universidad de Chile - Chile Tufts University - Estados Unidos Tufts University School of Medicine - Estados Unidos |
| 6 | Jeunemaitre, Xavier | Hombre |
Univ Paris 05 - Francia
Hopital Europeen Georges-Pompidou - Francia |
| 7 | Hopkins, Paul | Hombre |
Univ Utah - Estados Unidos
University of Utah - Estados Unidos University of Utah School of Medicine - Estados Unidos |
| 8 | Yao, Tham M. | - |
Harvard University - Estados Unidos
Brigham and Women's Hospital - Estados Unidos Harvard Medical School - Estados Unidos |
| 9 | Williams, Jonathan P. P. | Hombre |
Harvard University - Estados Unidos
Brigham and Women's Hospital - Estados Unidos Harvard Medical School - Estados Unidos |
| 10 | Adler, Gail K. | Mujer |
Harvard University - Estados Unidos
Brigham and Women's Hospital - Estados Unidos Harvard Medical School - Estados Unidos |
| 11 | Williams, Gordon | Hombre |
Harvard University - Estados Unidos
Brigham and Women's Hospital - Estados Unidos Harvard Medical School - Estados Unidos |
| Fuente |
|---|
| National Institutes of Health |
| National Heart, Lung, and Blood Institute |
| INSERM |
| National Center for Advancing Translational Sciences |
| Doris Duke Charitable Foundation |
| National Institute of Diabetes and Digestive and Kidney Diseases |
| Harvard Catalyst \ The Harvard Clinical and Translational Science Center (NCRR) |
| Chilean National Science and Technology Research Fund (FONDECYT) |
| French Ministry of Health |
| Harvard Catalyst \ The Harvard Clinical and Translational Science Center (NCATS, NIH Award) |
| Harvard Catalyst \ The Harvard Clinical and Translational Science Center (NCRR) |
| Harvard Catalyst \ The Harvard Clinical and Translational Science Center (NCATS, NIH Award) |
| Agradecimiento |
|---|
| This work was conducted with support from Harvard Catalyst vertical bar The Harvard Clinical and Translational Science Center (NCRR and NCATS, NIH Award UL1 TR001102), and the following grants, as well, from the National Institutes of Health: HL104032 (Dr Pojoga), K23HL111771 (Dr Vohringer), K24 HL103845 (Dr Adler), R01 HL087060-01 (Dr Adler), HL-69208 (Dr Williams), T32HL007609 (Dr Williams), R01HL11476 (Dr Williams), funds from INSERM and the French Ministry of Health (Dr Jeunemaitre), from the Doris Duke Charitable Foundation (Dr Vaidya) and from the Chilean National Science and Technology Research Fund (FONDECYT) 1130427 (Dr Baudrand), 1150437 (Dr Baudrand), 1150327(Dr Baudrand) and CORFO 13CTI-21526-P1 (Dr Baudrand). |
