The origin of spatial variations in the geochemical characteristics of volcanic rocks erupted in the Andean Southern Volcanic Zone (SVZ) has been studied by numerous researchers over the past 40 years. Diverse interpretations for along-strike, across-strike, and small-scale variations have been proposed. In this paper, we review geochemical data showing along-strike geochemical variations and address the processes causing such trends. We compare large- and small-scale changes of the same geochemical parameters in basaltic rocks in order to use spatial scale as a tool for isolating processes that may have the same result. Along-strike geochemical variations in the SVZ are expected, due to 1) greater thickness or age of the sub-arc continental crust and mantle lithosphere in the Northern SVZ (NSVZ; 33 degrees S -34 degrees 30'S) and Transitional SVZ (TSVZ; 34 degrees 30'S -37 degrees S) compared with the Central SVZ (CSVZ; 37 degrees S-41.5 degrees S) and Southern SVZ (SSVZ: 41.5 degrees S-46 degrees S); and 2) along-strike changes of the subducting Nazca plate and overlying asthenosphere. Basalts and basaltic andesites erupted at volcanic front stratovolcanoes define several along-strike geochemical trends: 1) higher Sr-87/Sr-86 and lower Nd-143/Nd-144 at volcanoes in the NSVZ compared with the TSVZ, CSVZ, and SSVZ; 2) higher and more variable La/Yb at volcanoes in the NSVZ and TSVZ compared with the CSVZ and SSVZ; 3) lower 87Sr/86Sr for a given Nd-143/Nd-144 at volcanoes in the TSVZ compared with the CSVZ and SSVZ; and 4) large values for time sensitive subduction tracers such as Be-10/Be-9 and (U-238/(23) Th) at some volcanoes in the CSVZ, but not in the NSVZ and TSVZ. Geochemical parameters that distinguish the TSVZ from the CSVZ and SSVZ are also found within the CSVZ at small basaltic eruptive centers (SEC) aligned with the Liquifie-Ofgui Fault System (LOFS), which extends from 38 S to the southernmost SVZ. Our interpretation is that CSVZ magmas with strong time-sensitive subduction tracers represent the ambient subduction-modified asthenosphere beneath the SVZ and that TSVZ magmas and some SEC in the CSVZ are modified by interaction with pyroxenite during ascent through the mantle lithosphere. In the CSVZ and probably the SSVZ, enhanced crustal permeability created by the LOFS allows the eruption of geochemically diverse magmas on a small scale. In the TSVZ and the NSVZ, the composition of magma from the subduction-modified asthenosphere is overprinted by interaction with the mantle lithosphere. (C) 2016 Elsevier B.V. All rights reserved.