The promoting effect of Cu on Re/SiO2 catalysts was studied for guaiacol hydrodeoxygenation. Cu(x)Re/SiO2 catalysts containing from 0 to 1.91 wt% Cu and 13 wt% of Re were prepared by successive wet impregnation and characterized using X-ray diffraction (XRD), nitrogen sorption, CO chemisorption, X-ray photoelectron spectroscopy (XPS), X-ray absorption spectroscopy (XAS) and surface acidity techniques. Batch reactions were carried out at 300 degrees C and 5 MPa of H-2. The Cu(x)Re/SiO2 catalysts displayed higher activities than the Re/SiO2 catalyst with a maximum activity at 1.58 wt% Cu. At loadings above 1.5 wt%, aggregate formation and a loss of metallic Re active sites lead to a decreased activity. The increase of the activity was attributed not only to Cu increasing the Re reducibility, but also to Cu somehow increasing the metallic Re active sites favoring guaiacol conversion. All catalysts displayed the same product distribution, confirming that the Cu in the Cu(x)Re/SiO2 not change the nature of the active site in the metallic Re nanoparticles. (C) 2016 Elsevier Ltd. All rights reserved.