The aim of this study was to assess the validity (differential/discriminant) and the sensitivity and specificity of Depression in Men Questionnaire. In the clinical sample, there were 59 men and 59 women between 18 and 65 years previously diagnosed with depression, which were compared with each other and with a sample of controls with similar demographic characteristics. As a contrast it was the professional concept and MINI interview Depression. For psychometric analyzes the Rasch model was used from the Item Response Theory and analysis of covariance between the measurements were made. It is concluded that the instrument has a high level of validity and reliability, and has a level of sensitivity and similar to the contrast scale specificity.