Crustal faults located close to cities may induce catastrophic damages. When recurrence times are in the range of 1000-10000 or higher, actions to mitigate the effects of the associated earthquake are hampered by the lack of a full seismic record, and in many cases, also of geological evidences. In order to characterize the fault behavior and its effects, we propose three different already-developed time-integration methodologies to define the most likely scenarios of rupture, and then to quantify the hazard with an empirical equation of peak ground acceleration (PGA). We consider the following methodologies: (1) stream gradient and (2) sinuosity indexes to estimate fault-related topographic effects, and (3) gravity profiles across the fault to identify the fault scarp in the basement. We chose the San Ramon Fault on which to apply these methodologies. It is a similar to 30 km N-S trending fault with a low slip rate (0.1-0.5 mm yr(-1)) and an approximated recurrence of 9000 years. It is located in the foothills of the Andes near the large city of Santiago, the capital of Chile (> 6 000 000 inhabitants). Along the fault trace we define four segments, with a mean length of similar to 10 km, which probably become active independently. We tested the present-day seismic activity by deploying a local seismological network for 1 year, finding five events that are spatially related to the fault. In addition, fault geometry along the most evident scarp was imaged in terms of its electrical resistivity response by a high resolution TEM (transient electromagnetic) profile. Seismic event distribution and TEM imaging allowed the constraint of the fault dip angle (similar to 65 degrees) and its capacity to break into the surface. Using the empirical equation of Chiou and Youngs (2014) for crustal faults and considering the characteristic seismic event (thrust high-angle fault, similar to 10 km, M-w D 6.2-6.7), we estimate the acceleration distribution in Santiago and the hazardous zones. City domains that are under high risk include the hanging wall zone covered by sediments and narrow zones where the fault could break the surface. Over these domains horizontal PGA can be greater than 0.5 g and eventually produce building collapse.