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| DOI | 10.2174/1385272821666161201121344 | ||||
| Año | 2017 | ||||
| Tipo | revisión |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Several organic compounds especially cyclic compounds containing double or triple bond and carbonyl compounds, aromatic compounds were brominated by employing several well-known reagents e.g., N-bromosuccinimide, bromine in acetic acid, ammonium bromide, hydrogen peroxide in acetic acid, carbon tetrabromide, phosphorous tribromide, 2,4,4,6-tetrabromocyclohex-2,5-dienone. The resulting compounds were utilized for the synthesis of several sesquiterpenes e.g., eudes-4(14)7(11)-diene-8-one, glutinosone, platyphyllide, occidentalol, drim-8-ene-7-one, cacalol, elemol, bakkenolide A, 10-bromo-alpha-chamigrene, allolaurintero, aplysin, costunolide, humulene, bisabollenes, bicycloelemene, occidol, longifolin, juvabiols, futronolide, etc. The importance of some of the mentioned reagents for bromination was also observed during the synthesis of the plant hormone abscisic acid, marine terpene synderol and alpha-asarone, a substance of potent hypolipidemic activity. The compounds obtained by bromination were likewise utilized for the synthesis of diterpenes like taxodione, spat-13,17-dien-5-ol and gibberellin A(12). Some of these bromo compounds were utilized for the synthesis of many substituted tetralones, tetralins and naphthalenes e.g., 6,7-dimethoxy-2-tetralone, 8-methyl-7-methoxy-1-tetralone, 8-methyl-1-tetralone, 1,4-dimethoxy-1-acetylnaphthalene, 7-methoxy-1-naphthylacetic acid, 5,6-dimethoxy1,2,3,4-tetrahydronaphthalene-2-carboxylic acid, 2-hydroxy-1,4-dimethoxynaphthalene which were utilized for the synthesis of many bioactive compounds.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Poon, Po Shan | - |
Inst Venezolano Invest Cient IVIC - Venezuela
Universidad de Concepción - Chile Instituto Venezolano de Investigaciones Científicas - Venezuela |
| 2 | Banerjee, Ajoy K. | - |
Inst Venezolano Invest Cient IVIC - Venezuela
Instituto Venezolano de Investigaciones Científicas - Venezuela |
| 3 | Vera, William J. | Hombre |
Inst Venezolano Invest Cient IVIC - Venezuela
Instituto Venezolano de Investigaciones Científicas - Venezuela |
| 4 | Bedoya, Liadis | - |
Inst Venezolano Invest Cient IVIC - Venezuela
Instituto Venezolano de Investigaciones Científicas - Venezuela |