The problem of vitalism in philosophy of Gilles Deleuze wanders his entire work implicating an appeal: to liberate life from any kind of subjugation. Vitalism is not mere content, since vitalism expresses in Deleuze his own point of view about philosophy as creation of concepts. Thus, a presentation of what implicates a Deleuzian vitalism demands to be raised in the context of his thought, avoiding interpretation, to, finally, repeat his philosophy. Following this idea, we move after into the reading of Nietzsche's philosophy, specifically into the conceived difference among monumental history, antiquarian history and critical history, argued to delimitate basics precepts for a useful history for life. Then, in a second moment, ideas and comments created at II Untimely By Nietzsche will be developed as part of Deleuze own work. Deleuze try to balance in his work metaphysics, history of philosophy and critic, in order to produce a philosophy useful for life, considering the difference between what we are ceasing to be, our immediate past, and what we are becoming, our immediate future. Finally, after this preparation, it is exposed, through the notion of diagram, the major consequences of vitalism in Gilles Deleuze, expression of philosophy useful for life or diagnosis of new possibilities for life in what scape of present.