In recent years, persistent quasi-zonal jets or striations have been ubiquitously detected in the world ocean using satellite and in situ data as well as numerical models. This study aims at determining the role of mesoscale eddies in the generation and persistence of striations off Chile in the eastern South Pacific. A 50 year climatological integration of an eddy-resolving numerical ocean model is used to assess the long-term persistence of striations. Automated eddy tracking algorithms are applied to the model outputs and altimetry data. Results reveal that striations coincide with both polarized eddy tracks and the offshore formation of new eddies in the subtropical front and coastal transition zone, without any significant decay over time that discards random eddies as a primary driver of the striations. Localized patches of vortex stretching and relative vorticity advection, alternating meridionally near the eastern edge of the subtropical front, are associated with topographic steering of the background flow in the presence of steep topography, and with baroclinically and barotropically unstable meridional flow. These sinks and sources of vorticity are suggested to generate the banded structure further west, consistently with a -plume mechanism. On the other hand, zonal/meridional eddy advection of relative vorticity and the associated Reynolds stress covariance are consistent with eddy deformation over rough topography and participate to sustain the striations in the far field. Shear instability of mean striations is proposed to feedback onto the eddy field, acting to maintain the subtropical front eddy streets and thus the striations.