Dataciencia

Colección SciELO Chile

Cognitive Variability during Middle-Age: Possible Association with Neurodegeneration and Cognitive Reserve

Indexado

WoS	WOS:000403762500001
Scopus	SCOPUS_ID:85020942440

DOI

10.3389/FNAGI.2017.00188

Año

2017

Tipo

artículo de investigación

Citas Totales

Autores Afiliación Chile

Instituciones Chile

% Participación
Internacional

Autores
Afiliación Extranjera

Instituciones
Extranjeras

Abstract

Conclusion: Variability in cognition during middle-age is associated with neurodegeneration in the parietal-temporal-occipital association cortex and white matter tracts connecting this to the prefrontal dorsolateral cortex and the hippocampus. Moreover, this effect is influenced by cognitive reserve. Studying variability offers valuable information showing that differences do not occur in the same magnitude and direction across individuals, cognitive domains and tasks. These findings may have important implications for early detection of subtle cognitive impairment and clinical interpretation of deviation from normality.

Revista

Revista	ISSN
Frontiers In Aging Neuroscience	1663-4365

Métricas Externas

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Disciplinas de Investigación

WOS
Neurosciences
Geriatrics & Gerontology

Scopus
Sin Disciplinas

SciELO
Sin Disciplinas

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Publicaciones WoS (Ediciones: ISSHP, ISTP, AHCI, SSCI, SCI), Scopus, SciELO Chile.

Colaboración Institucional

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Autores - Afiliación

Ord.	Autor	Género	Institución - País
1	Ferreira, Daniel	Hombre	Karolinska Inst - Suecia UNIV LA LAGUNA - España Karolinska Institutet - Suecia Universidad de La Laguna - España
2	Machado, Alejandra	Mujer	Karolinska Inst - Suecia UNIV LA LAGUNA - España Karolinska Institutet - Suecia Universidad de La Laguna - España
3	Molina, Yaiza	-	UNIV LA LAGUNA - España Univ Fernando Pessoa Canarias - España Universidad de La Laguna - España Universidad Fernando Pessoa Canarias - España
4	Nieto, Antonieta	Mujer	UNIV LA LAGUNA - España Universidad de La Laguna - España
5	CORREIA-DELGADO, RUT	-	UNIV LA LAGUNA - España Universidad Diego Portales - Chile Universidad de La Laguna - España
6	Westman, Eric	Hombre	Karolinska Inst - Suecia Karolinska Institutet - Suecia
7	Barroso, Jose	Hombre	UNIV LA LAGUNA - España Universidad de La Laguna - España

Muestra la afiliación y género (detectado) para los co-autores de la publicación.

Financiamiento

Fuente
Ministerio de Ciencia e Innovación
VetenskapsrÃ¥det
Vetenskapsradet
Universidad de La Laguna
Swedish Research Council (VR)
Stiftelsen fÃ¶rÂ Strategisk Forskning
Fundacion Cajacanarias
Hjarnfonden
Swedish Foundation for Strategic Research (SSF)
Servicio de Resonancia Magnetica para Investigaciones Biomedicas del SEGAI (University of La Laguna, Spain)
Fundacion Canaria Dr. Manuel Morales
Birgitta och Sten Westerberg
Manuel Urbano
Pedro Velasco
Ministerio de Ciencia e Innovaci?n
University of La Laguna
Stiftelsen för Strategisk Forskning
Fundación Canaria
Servicio de Resonancia Magnética para Investigaciones Biomédicas del SEGAI

Muestra la fuente de financiamiento declarada en la publicación.

Agradecimientos

Agradecimiento
This study was funded by Ministerio de Ciencia e Innovacion (Project SEJ2006-14796; Grant BES-2007-15658); Fundacion Canaria Dr. Manuel Morales (convocatoria 2012 y convocatoria 2014); Fundacion Cajacanarias; Servicio de Resonancia Magnetica para Investigaciones Biomedicas del SEGAI (University of La Laguna, Spain); the Swedish Foundation for Strategic Research (SSF); the Swedish Research Council (VR); Hjarnfonden; and Birgitta och Sten Westerberg. The funders of the study had no role in the study design nor the collection, analysis, and interpretation of data, writing of the report, or decision to submit the manuscript for publication.
This study was funded by Ministerio de Ciencia e Innovación (Project SEJ2006-14796; Grant BES-2007-15658); Fundación Canaria Dr. Manuel Morales (convocatoria 2012 y convocatoria 2014); Fundación Cajacanarias; Servicio de Resonancia Magnética para Investigaciones Biomédicas del SEGAI (University of La Laguna, Spain); the Swedish Foundation for Strategic Research (SSF); the Swedish Research Council (VR); Hjärnfonden; and Birgitta och Sten Westerberg. The funders of the study had no role in the study design nor the collection, analysis, and interpretation of data, writing of the report, or decision to submit the manuscript for publication. The authors would like to thank Dr. Diaz-Flores Varela (Hospital Universitario de Canarias, Tenerife, Spain) for his collaboration in the inspection of magnetic resonance images for inclusion criteria; Stephany Hess (Faculty of Psychology, University of La Laguna, Spain) for her statistical advice; Dr. Antonio Rodríguez for providing access to participants and helpful assistance; Soheil Damangir (Division of Clinical Geriatrics, Karolinska Institutet, Sweden) for his assistance on the CASCADE software; Ministerio de Ciencia e Innovación (Project SEJ2006-14796; Grant BES-2007-15658); Fundación Canaria Dr. Manuel Morales (convocatoria 2012 y convocatoria 2014); Fundación Cajacanarias; Servicio de Resonancia Magnética para Investigaciones Biomédicas del SEGAI (University of La Laguna, Spain); the Swedish Foundation for Strategic Research (SSF); the Swedish Research Council (VR); Hjärnfonden; and Birgitta och Sten Westerberg. The funders of the study had no role in the study design nor the collection, analysis, and interpretation of data, writing of the report, or decision to submit the manuscript for publication. Data used in preparation of this article is part of the GENIC-database (Group of Neuropsychological Studies of the Canary Islands, University of La Laguna, Spain. Principal investigator: Professor José Barroso). The following collaborators contributed to the GENIC-database but did not participate in analysis or writing of this report (in alphabetic order by family name): Nira Cedrés, Patricia Díaz, Nerea Figueroa, Iván Galtier, Lissett González, Teodoro González, Zaira González, Cathaysa Hernández, Edith Hernández, Nira Jiménez, Judith López, María Sabucedo, Elena Sirumal, Marta Suárez, Manuel Urbano, Pedro Velasco

Agradecimiento

This study was funded by Ministerio de Ciencia e Innovacion (Project SEJ2006-14796; Grant BES-2007-15658); Fundacion Canaria Dr. Manuel Morales (convocatoria 2012 y convocatoria 2014); Fundacion Cajacanarias; Servicio de Resonancia Magnetica para Investigaciones Biomedicas del SEGAI (University of La Laguna, Spain); the Swedish Foundation for Strategic Research (SSF); the Swedish Research Council (VR); Hjarnfonden; and Birgitta och Sten Westerberg. The funders of the study had no role in the study design nor the collection, analysis, and interpretation of data, writing of the report, or decision to submit the manuscript for publication.

This study was funded by Ministerio de Ciencia e Innovación (Project SEJ2006-14796; Grant BES-2007-15658); Fundación Canaria Dr. Manuel Morales (convocatoria 2012 y convocatoria 2014); Fundación Cajacanarias; Servicio de Resonancia Magnética para Investigaciones Biomédicas del SEGAI (University of La Laguna, Spain); the Swedish Foundation for Strategic Research (SSF); the Swedish Research Council (VR); Hjärnfonden; and Birgitta och Sten Westerberg. The funders of the study had no role in the study design nor the collection, analysis, and interpretation of data, writing of the report, or decision to submit the manuscript for publication. The authors would like to thank Dr. Diaz-Flores Varela (Hospital Universitario de Canarias, Tenerife, Spain) for his collaboration in the inspection of magnetic resonance images for inclusion criteria; Stephany Hess (Faculty of Psychology, University of La Laguna, Spain) for her statistical advice; Dr. Antonio Rodríguez for providing access to participants and helpful assistance; Soheil Damangir (Division of Clinical Geriatrics, Karolinska Institutet, Sweden) for his assistance on the CASCADE software; Ministerio de Ciencia e Innovación (Project SEJ2006-14796; Grant BES-2007-15658); Fundación Canaria Dr. Manuel Morales (convocatoria 2012 y convocatoria 2014); Fundación Cajacanarias; Servicio de Resonancia Magnética para Investigaciones Biomédicas del SEGAI (University of La Laguna, Spain); the Swedish Foundation for Strategic Research (SSF); the Swedish Research Council (VR); Hjärnfonden; and Birgitta och Sten Westerberg. The funders of the study had no role in the study design nor the collection, analysis, and interpretation of data, writing of the report, or decision to submit the manuscript for publication. Data used in preparation of this article is part of the GENIC-database (Group of Neuropsychological Studies of the Canary Islands, University of La Laguna, Spain. Principal investigator: Professor José Barroso). The following collaborators contributed to the GENIC-database but did not participate in analysis or writing of this report (in alphabetic order by family name): Nira Cedrés, Patricia Díaz, Nerea Figueroa, Iván Galtier, Lissett González, Teodoro González, Zaira González, Cathaysa Hernández, Edith Hernández, Nira Jiménez, Judith López, María Sabucedo, Elena Sirumal, Marta Suárez, Manuel Urbano, Pedro Velasco