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Endothelial cAMP deactivates ischemia-reperfusion-induced microvascular hyperpermeability via Rap1-mediated mechanisms
| Indexado |
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| DOI | 10.1152/AJPHEART.00002.2017 | ||||
| Año | 2017 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
NEW & NOTEWORTHY Here, we demonstrate that 1) stimulation of cAMP production deactivates ischemia-reperfusion-induced hyperpermeability in muscle and endothelial cells; 2) VEGF mRNA expression is not enhanced by brief ischemia, suggesting that VEGF mechanisms do not activate immediate postischemic hyperpermeability; and 3) deactivation mechanisms operate via cAMP-exchange protein activated by cAMP 1-Rap1 to restore integrity of the endothelial barrier.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Korayem, Adam | Hombre |
Univ Med & Dent New Jersey - Estados Unidos
RUTGERS STATE UNIV - Estados Unidos Rutgers New Jersey Medical School - Estados Unidos School of Graduate Studies - Estados Unidos |
| 2 | Mujica, Patricio | Hombre |
RUTGERS STATE UNIV - Estados Unidos
School of Graduate Studies - Estados Unidos |
| 3 | Aramoto, Haruo | Hombre |
Univ Med & Dent New Jersey - Estados Unidos
Rutgers New Jersey Medical School - Estados Unidos |
| 4 | Duran, Ricardo G. | Hombre |
Univ Med & Dent New Jersey - Estados Unidos
Rutgers New Jersey Medical School - Estados Unidos |
| 5 | Nepali, Prerna R. | - |
RUTGERS STATE UNIV - Estados Unidos
School of Graduate Studies - Estados Unidos |
| 6 | Kim, David D. | Hombre |
Univ Med & Dent New Jersey - Estados Unidos
Rutgers New Jersey Medical School - Estados Unidos |
| 7 | Harris, Andrew L. | Hombre |
Univ Med & Dent New Jersey - Estados Unidos
RUTGERS STATE UNIV - Estados Unidos Rutgers New Jersey Medical School - Estados Unidos School of Graduate Studies - Estados Unidos |
| 8 | SANCHEZ-VASQUEZ, FABIOLA ALEJANDRA | Mujer |
Universidad Austral de Chile - Chile
|
| 9 | Duran, Walter N. | Hombre |
Univ Med & Dent New Jersey - Estados Unidos
RUTGERS STATE UNIV - Estados Unidos Rutgers New Jersey Medical School - Estados Unidos School of Graduate Studies - Estados Unidos |
| Fuente |
|---|
| Fondo Nacional de Desarrollo Científico y Tecnológico |
| National Heart, Lung, and Blood Institute |
| Chile's Fondecyt |
| Chile?s Fondecyt |
| Agradecimiento |
|---|
| This work was supported by National Heart, Lung, and Blood Institute Grants 5-R01-HL-070634 and 5-R01-HL-088479 and Chile's Fondecyt 1130769. |
| This work was supported by National Heart, Lung, and Blood Institute Grants 5-R01-HL-070634 and 5-R01-HL-088479 and Chile’s Fondecyt 1130769. |
