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ISN Nexus 2016 Symposia: Translational Immunology in Kidney Disease—The Berlin Roadmap
| Indexado |
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| DOI | 10.1016/J.EKIR.2016.06.009 | ||||
| Año | 2016 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
To date, the treatment of immune-mediated kidney diseases has only marginally benefited from highly specific biological drugs that have demonstrated remarkable effects in many other diseases. What accounts for this disparity? In April 2016, the International Society of Nephrology held a Nexus meeting on Translational Immunology in Nephrology in Berlin, Germany, to identify and discuss hurdles that block the translational flow of target identification, and preclinical and clinical target validation in the domain of immune-mediated kidney disease. A broad panel of experts including basic scientists, translational researchers, clinical trialists, pharmaceutical industry drug developers, and representatives of the American and European regulatory authorities made recommendations on how to overcome such hurdles at all levels of the translational research process. The results of these discussions are presented here, which may serve as a roadmap for how to optimize the process of developing more innovative and effective drugs for patients with immune-mediated kidney diseases.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Anders, Hans-Joachim | - |
Klinikum Ludwig Maximilians Univ Munchen - Alemania
|
| 1 | Anders, Hans-Joachim | Hombre |
Klinikum der Universität München - Alemania
Klinikum Ludwig Maximilians Univ Munchen - Alemania |
| 2 | Rovin, Brad | Hombre |
OHIO STATE UNIV - Estados Unidos
The Ohio State University Wexner Medical Center - Estados Unidos |
| 3 | Jayne, David | Hombre |
Addenbrookes Hosp - Reino Unido
Addenbrooke's Hospital - Reino Unido |
| 4 | Brunetta, Paul | Hombre |
Genentech Inc - Estados Unidos
Genentech Incorporated - Estados Unidos Genentech, Inc - Estados Unidos |
| 5 | Coppo, Rosanna | Mujer |
AOU Citta Salute Sci Torino - Italia
Regina Margherita Hosp - Italia Ospedale Infantile Regina Margherita - Italia |
| 6 | Davidson, Anne | Mujer |
Feinstein Inst Med Res - Estados Unidos
Feinstein Institute for Medical Research - Estados Unidos |
| 7 | Devarapu, Satish Kumar | Hombre |
Klinikum Ludwig Maximilians Univ Munchen - Alemania
Klinikum der Universität München - Alemania |
| 8 | de Zeeuw, Dick | Hombre |
Univ Groningen - Países Bajos
University of Groningen, University Medical Center Groningen - Países Bajos Universitair Medisch Centrum Groningen - Países Bajos |
| 9 | Duffield, Jeremy | Hombre |
Biogen Inc - Estados Unidos
Research & Development - Estados Unidos Worldwide Research & Development - Estados Unidos |
| 10 | Eulberg, Dirk | Hombre |
NOXXON Pharma AG - Alemania
|
| 11 | Fierro, Alberto | Hombre |
Clínica Las Condes - Chile
|
| 12 | Floege, Jürgen | Hombre |
Uniklinik RWTH Aachen - Alemania
|
| 12 | Floege, Juergen | - |
Rhein Westfal TH Aachen - Alemania
Uniklinik RWTH Aachen - Alemania |
| 13 | Frese, Steffen | Hombre |
Evangel Lungenklin Berlin - Alemania
Evangelische Lungenklinik Berlin - Alemania |
| 14 | Guillevin, Loic | - |
Univ Paris 05 - Francia
Hop Cochin - Francia Université de Paris - Francia Université Paris Cité - Francia |
| 15 | Holdsworth, Stephen | Hombre |
MONASH UNIV - Australia
Monash University - Australia Monash Medical Centre - Australia |
| 16 | Hughes, Jeremy | Hombre |
UNIV EDINBURGH - Reino Unido
University of Edinburgh - Reino Unido The University of Edinburgh - Reino Unido |
| 17 | Kettritz, Ralph | Hombre |
Campus Virchow Klinikum - Alemania
Charite Med Fac - Alemania Charité – Universitätsmedizin Berlin - Alemania |
| 18 | Kluger, Malte | Hombre |
Univ Med Ctr - Alemania
Universitätsklinikum Hamburg-Eppendorf und Medizinische Fakultät - Alemania Universitätsklinikum Hamburg-Eppendorf - Alemania |
| 19 | Krebs, Christian | Hombre |
Univ Med Ctr - Alemania
Universitätsklinikum Hamburg-Eppendorf und Medizinische Fakultät - Alemania Universitätsklinikum Hamburg-Eppendorf - Alemania |
| 20 | Lapteva, Larissa | Mujer |
US FDA - Estados Unidos
Food and Drug Administration - Estados Unidos |
| 21 | Levin, Adeera | - |
UNIV BRITISH COLUMBIA - Canadá
The University of British Columbia - Canadá |
| 22 | Li, Jinhua | - |
MONASH UNIV - Australia
Monash University - Australia |
| 23 | Lightstone, Liz | - |
Imperial Coll London - Reino Unido
Imperial College London - Reino Unido |
| 24 | Mack, Matthias | Hombre |
Univ Regensburg - Alemania
Universität Regensburg - Alemania Klinikum der Universität Regensburg und Medizinische Fakultät - Alemania |
| 25 | Mansouri, Ladan | Mujer |
Karolinska Inst - Suecia
Karolinska Univ Hosp Solna - Suecia Karolinska University Hospital - Suecia Karolinska Universitetssjukhuset - Suecia |
| 26 | McAdoo, Stephen | Hombre |
Imperial Coll London - Reino Unido
Imperial College London - Reino Unido |
| 27 | McKinney, Eoin | Hombre |
UNIV CAMBRIDGE - Reino Unido
School of Clinical Medicine - Reino Unido Addenbrooke's Hospital - Reino Unido |
| 28 | Panzer, Ulf | - |
Univ Med Ctr - Alemania
Universitätsklinikum Hamburg-Eppendorf und Medizinische Fakultät - Alemania Universitätsklinikum Hamburg-Eppendorf - Alemania |
| 29 | Parikh, Samir | Hombre |
OHIO STATE UNIV - Estados Unidos
The Ohio State University Wexner Medical Center - Estados Unidos |
| 30 | Pusey, Charles | Hombre |
Imperial Coll London - Reino Unido
Imperial College London - Reino Unido |
| 31 | Putterman, Chaim | Hombre |
Albert Einstein Coll Med - Estados Unidos
Albert Einstein College of Medicine of Yeshiva University - Estados Unidos |
| 32 | Rabelink, Ton | - |
Leiden Univ - Países Bajos
Leiden University Medical Center - LUMC - Países Bajos Leids Universitair Medisch Centrum - Países Bajos |
| 33 | Radbruch, Andreas | Hombre |
Deutsch Rheuma Forschungszentrum Berlin - Alemania
Deutsches Rheuma-Forschungszentrum - Alemania |
| 34 | Rees, Andrew | Hombre |
Med Univ Vienna - Austria
Medizinische Universitat Wien - Austria |
| 35 | Reilly, Mary | Mujer |
Opsona Therapeut Ltd - Irlanda
Opsona Therapeutics Ltd. - Irlanda |
| 36 | Reinders, Marlies | Mujer |
Leiden Univ - Países Bajos
Leiden University Medical Center - LUMC - Países Bajos Leids Universitair Medisch Centrum - Países Bajos |
| 37 | Remuzzi, Giuseppe | Hombre |
IRCCS Ist Ric Farmacol Mario Negri - Italia
Laboratori Negri Bergamo - Italia Istituto di Ricerche Farmacologiche Mario Negri - Italia |
| 38 | Ruggenenti, Piero | Hombre |
IRCCS Ist Ric Farmacol Mario Negri - Italia
Azienda Osped Papa Giovanni XXIII - Italia Laboratori Negri Bergamo - Italia Azienda Ospedaliera Papa Giovanni XXIII - Italia Istituto di Ricerche Farmacologiche Mario Negri - Italia |
| 39 | Sacks, Steven | Hombre |
Kings Coll London - Reino Unido
King's College London - Reino Unido |
| 40 | Schall, Thomas J. | Hombre |
ChemoCentryx - Estados Unidos
ChemoCentryx, Inc. - Estados Unidos |
| 41 | Meyer-Schwesinger, Catherine | Mujer |
Univ Med Ctr - Alemania
Universitätsklinikum Hamburg-Eppendorf und Medizinische Fakultät - Alemania Universitätsklinikum Hamburg-Eppendorf - Alemania |
| 42 | Sharma, Kumar | Hombre |
Univ Calif San Diego - Estados Unidos
University of California, San Diego - Estados Unidos |
| 43 | Suzuki, Yusuke | Hombre |
Juntendo Univ - Japón
Juntendo University - Japón Juntendo University School of Medicine - Japón |
| 44 | Tomas, Nicola M. | Mujer |
Univ Med Ctr - Alemania
Universitätsklinikum Hamburg-Eppendorf und Medizinische Fakultät - Alemania Universitätsklinikum Hamburg-Eppendorf - Alemania |
| 45 | Zhao, Ming Hui | - |
Peking Univ - China
|
| 45 | Zhao, Ming Hui | - |
Peking University First Hospital - China
Peking Univ - China |
| Fuente |
|---|
| Fondo Nacional de Desarrollo Científico y Tecnológico |
| European Union |
| Fondecyt Regular |
| Seventh Framework Programme |
| Fondo Nacional de Desarrollo CientÃfico y Tecnológico |
| EU |
| Horizon 2020 |
| European Union's Horizon 2020 research and innovation program |
| HORIZON2020 project NEPHSTROM |
| Agradecimiento |
|---|
| We thank the International Society of Nephrology for hosting the Nexus meeting and the industry sponsors for their unrestricted educational support. The study was supported by the European Union's Horizon 2020 research and innovation program under grant agreement No. 668036 (RELENT). This report was further supported by the EU 7FP project REDDSTAR (No. 305736) and the HORIZON2020 project NEPHSTROM (No. 634086). The views expressed here are the responsibility of the author(s) only. The EU Commission takes no responsibility for any use made of the information set out. Alberto Fierro, Chile, was supported by "Fondecyt regular 1120731." |
| We thank the International Society of Nephrology for hosting the Nexus meeting and the industry sponsors for their unrestricted educational support. The study was supported by the European Union's Horizon 2020 research and innovation program under grant agreement No. 668036 (RELENT). This report was further supported by the EU 7FP project REDDSTAR (No. 305736) and the HORIZON2020 project NEPHSTROM (No. 634086). The views expressed here are the responsibility of the author(s) only. The EU Commission takes no responsibility for any use made of the information set out. Alberto Fierro, Chile, was supported by “Fondecyt regular 1120731.” |
