Conclusion: Infantile cortical hyperostosis is a collagenopathy, which must be considered as a differential diagnosis in acute bone inflammatory processes, irritability and fever. It is important to understand and identify this disease and clinical-radiological correlation is remarkable. (C) 2016 Sociedad Chilena de PediatrIia. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license.