Introduction - Stone pine (Pinus pinea L.) is a species of economic interest for its pine nuts. Despite this market, cones are harvested mostly from natural forests. Advances in semi-intensive or intensive management for cultivating it as a fruit tree have been scarce. Fruit development is characterized by a 3-year cycle since pollination to harvesting, making nutritional and hydric management highly challenging. Materials and methods - We studied the main and interaction effects of fertilization and irrigation on growth and fruiting by a factorial design laid out in an adult stone pine plantation located in central Chile. Results and discussion - Mineral fertilization had an effect one year later on height growth (+ 23.5% increase) and one-year-old conelet production (+ 82.3% increase). After two consecutive years of mineral fertilization, significant positive impacts on diameter growth, height growth and one-year-old conelet production were observed. Irrigation enhanced fruiting but did not impact growth significantly. The highest conelet number was observed in the fertilized and irrigated experimental plots. Conclusion - Both cultural practices, applied either individually or combined, are efficient techniques to enhance fruit production of the stone pine.