The aim of this study is to increase the phytochemical knowledge of South American bryophytes, particularly from those of the southern tip of the continent, due to the uniqueness of its poorly known bryoflora. Thirty-two specimens were analyzed using GC-MS technique. Most of the molecules found in the present bryophyte species belong to sesquiterpenes. In general, liverworts resulted to be richer in terpenoid compounds, while mosses in n-alkanes. Oplopanone, transchrysanthenyl acetate and 6,7-secoeudesm-7(11)-en-6-al are compounds here newly reported to the bryophytes. alpha-Ylangene and alpha-herbertenol are new to homworts, while a-herbertenol and n-heneicosane are new to mosses.