This article analyzes social and political practices deployed by curas doctrineros (rural priests) in charge of evaengelization of native groups within the pueblos de reduccion (villages) of the Titicaca lake corregimientos (provinces) between the late-16th and the mid-17th centuries. Notarial protocols, court records and formal presentations to higher colonial administration levels are addressed to inquire about local political framework, given that curas doctrineros, as well as caciques and corregidores, played key roles in the political dynamics of each pueblo de reduccion. We prone to settle comparative approaches on how curas and caciques built their political careers and to examine sociocultural intermediation instances carried out by both social actors.