This paper traces the birth, evolution and main achievements of the Network for a GE Free Latin America (RALLT), a regional network that coordinate spaces to support organizations that face the expansion of transgenic crops in the Latin American region. The network addresses the issue of GMOs from a variety of perspectives, including the health impacts that GM crops produces, the loss of biodiversity, and the dependence generated by the application of intellectual property rights in seeds. In this article, we describe the path that RALLT has followed from an historical and political perspective, and how and why RALLT was born. The analysis on how the network has constructed its identity as a Latin American network is presented, and on the necessity to establish dialogues among its members and with other actors. We show how RALLT has develop and build the spaces of solidarity and make a recount of the major issues in which the network has worked over the years and identified new and pending issues.