The “Firm, Lyft, and Relax” (FL&R) is a versatile approach that associates botulinum toxin (BTx), hyaluronic acid (HA), and collagen bioestimulators (CBio) treatments, suitable for patients of varying ages and diverse cosmetic concerns. This strategy considers factors such as facial static and dynamic areas, the requirement for projection or volumization, and tissue thickness and firmness. This study aims to elucidate the main concerns of the FL&R technique, presenting a series of four cases and providing a guide for clinicians using combined treatment modalities for facial rejuvenation. The treatments involved the strategic use of BTx, poly-L-lactic acid (PLLA), and HA. Following the treatments, all patients experienced significant aesthetic improvements, as evaluated through 3D stereophotogrammetry. It is important to note that while this approach yields satisfactory outcomes, it should not be standardized; rather, it should be tailored to meet the unique needs of each patient.