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Studies on the interaction of NMDA receptor antagonist memantine with cell membranes: A mini-review
| Indexado |
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| DOI | 10.1016/J.CBI.2018.01.022 | ||||
| Año | 2018 | ||||
| Tipo | revisión |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
Memantine is an NMDA receptor antagonist clinically used for the treatment of moderate to severe Alzheimer's disease. Currently, it is the only NMDA receptor antagonist drug marketed against this disease. Despite the large number of publications regarding its clinical and therapeutic use, studies related to its mechanism of action are still inconclusive. Knowledge of drug interactions with cell membranes may lead to the development of novel drugs for neurodegenerative diseases. The present mini-review aims to give an overview of the latest findings regarding the interaction of memantine with cell membranes, specifically with that of the human erythrocyte.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Zambrano, Pablo | Hombre |
Universidad de Concepción - Chile
|
| 2 | SUWALSKY-WEINSYMER, MARIO | Hombre |
Universidad de Concepción - Chile
|
| 3 | Jemiola-Rzeminska, M. | - |
Jagiellonian Univ - Polonia
Uniwersytet Jagielloński w Krakowie - Polonia Uniwersytet Jagiellonski - Polonia |
| 4 | Strzalka, Kazimierz | Hombre |
Jagiellonian Univ - Polonia
Uniwersytet Jagielloński w Krakowie - Polonia Uniwersytet Jagiellonski - Polonia |
| Fuente |
|---|
| FONDECYT |
| CONICYT-PFCHA |
| Fondo Nacional de Desarrollo Científico y Tecnológico |
| Comisión Nacional de Investigación Científica y Tecnológica |
| European Regional Development Fund |
| Fondo Nacional de Desarrollo CientÃfico y Tecnológico |
| European Regional Development Fund (project Malopolska Center of Biotechnology) |
| CONICYT-PFCHA Grant |
| Uniwersytet Jagielloński w Krakowie |
| Malopolska Center of Biotechnology |
| Faculty of Biochemistry, Biophysics and Biotechnology of Jagiellonian University |
| Agradecimiento |
|---|
| To FONDECYT (Project 1130043), CONICYT-PFCHA Grant (Doctorado Nacional/No 21160337 to P. Zambrano), European Regional Development Fund (contract No. POIG.02.01.00-12-167/08, project Malopolska Center of Biotechnology) and Faculty of Biochemistry, Biophysics and Biotechnology of Jagiellonian University. |
| To FONDECYT (Project 1130043), CONICYT-PFCHA Grant (Doctorado Nacional/Nº21160337 to P. Zambrano), European Regional Development Fund (contract No. POIG.02.01.00-12-167/08, project Malopolska Center of Biotechnology) and Faculty of Biochemistry, Biophysics and Biotechnology of Jagiellonian University. |
