The tidal energy sector is advancing rapidly, with multiple projects demonstrating the reliability of devices to generate clean electricity. As technology converges and matures, detailed tidal resource characterization is essential for identifying and assessing viable deployment sites. This investigation examines the tidal energy potential in the Strait of Magellan, a key connection between the Pacific and Atlantic Oceans in the Chilean Patagonia known for its strong tidal currents. A high-resolution, unstructured-mesh numerical model calibrated with field data from Acoustic Doppler Current Profilers (ADCP) and tidal gauges at the two main narrows of the Strait is implemented. The model is used to estimate power densities and assess energy yields under various turbine-rated velocities and operational scenarios. Results indicate sustained power densities exceeding 1 kW/m2 over a 67 km2 area throughout a lunar month, with localized peaks reaching 10 kW/m2 during spring tide. Energy yield simulations using synthetic power curves suggest promising sites for first and second generation tidal turbines. This study offers the first high-resolution model of tidal resources in the Strait of Magellan, highlighting its potential as a leading site for tidal energy generation in the southern hemisphere.