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Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits
| Indexado |
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| DOI | 10.1038/S41467-025-58574-Z | ||||
| Año | 2025 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
Here, we present a multi-omics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits conducted to date in Hispanic/Latino populations (nmax = 63,184). We conduct a meta-analysis of 16 type 2 diabetes and 19 lipid trait GWAS, identifying 20 genome-wide significant loci for type 2 diabetes, including one novel locus and novel signals at two known loci, based on fine-mapping. We also identify sixty-one genome-wide significant loci across the lipid/lipoprotein traits, including nine novel loci, and novel signals at 19 known loci through fine-mapping. Next, we analyze genetically regulated expression, perform Mendelian randomization, and analyze association with transcriptomic and proteomic measure using multi-omics data from a Hispanic/Latino population. Using this approach, we identify genes linked to type 2 diabetes and lipid/lipoprotein traits, including TMEM205 and NEDD9 for HDL cholesterol, TREH for triglycerides, and ANXA4 for type 2 diabetes.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Petty, Lauren E. | Mujer |
Vanderbilt Univ - Estados Unidos
Vanderbilt University Medical Center - Estados Unidos |
| 2 | Chen, Hung Hsin | - |
Vanderbilt Univ - Estados Unidos
Acad Sinica - Taiwán Vanderbilt University Medical Center - Estados Unidos Academia Sinica, Institute of Biomedical Sciences - Taiwán |
| 3 | Frankel, Elizabeth G. | - |
Vanderbilt Univ - Estados Unidos
Vanderbilt University Medical Center - Estados Unidos |
| 4 | Zhu, Wanying | - |
Vanderbilt Univ - Estados Unidos
Vanderbilt University Medical Center - Estados Unidos |
| 5 | Downie, Carolina G. | - |
Univ North Carolina Chapel Hill - Estados Unidos
UNC Gillings School of Global Public Health - Estados Unidos |
| 6 | Graff, M. | Hombre |
Univ North Carolina Chapel Hill - Estados Unidos
UNC Gillings School of Global Public Health - Estados Unidos |
| 7 | Lin, Phillip | - |
Vanderbilt Univ - Estados Unidos
Vanderbilt University Medical Center - Estados Unidos |
| 8 | Sharma, Priya | - |
Univ North Carolina Chapel Hill - Estados Unidos
UNC Gillings School of Global Public Health - Estados Unidos |
| 9 | Zhang, Xinruo | - |
Univ North Carolina Chapel Hill - Estados Unidos
UNC Gillings School of Global Public Health - Estados Unidos |
| 10 | Scartozzi, Alyssa C. | - |
Vanderbilt Univ - Estados Unidos
Vanderbilt University Medical Center - Estados Unidos |
| 11 | Roshani, Rashedeh | - |
Vanderbilt Univ - Estados Unidos
Vanderbilt University Medical Center - Estados Unidos |
| 12 | Landman, Joshua M. | - |
Vanderbilt Univ - Estados Unidos
Vanderbilt University Medical Center - Estados Unidos |
| 13 | Boehnke, Michael | Hombre |
UNIV MICHIGAN - Estados Unidos
University of Michigan School of Public Health - Estados Unidos |
| 14 | Bowden, Donald W. | Hombre |
Wake Forest Sch Med - Estados Unidos
Wake Forest University School of Medicine - Estados Unidos |
| 15 | Chambers, John C. | Hombre |
Imperial Coll London - Reino Unido
London North West Healthcare NHS Trust - Reino Unido Nanyang Technol Univ - Singapur Ealing Hospital - Reino Unido Lee Kong Chian School of Medicine - Singapur MRC Centre for Environment and Health - Reino Unido Imperial College Healthcare NHS Trust - Reino Unido |
| 16 | Mahajan, Anubha | - |
UNIV OXFORD - Reino Unido
University of Oxford Medical Sciences Division - Reino Unido Nuffield Department of Medicine - Reino Unido |
| 17 | McCarthy, Mark | Hombre |
University of Oxford Medical Sciences Division - Reino Unido
Nuffield Department of Medicine - Reino Unido NIHR Oxford Biomedical Research Centre - Reino Unido |
| 18 | Ng, Maggie C. Y. | Mujer |
Vanderbilt Univ - Estados Unidos
Wake Forest Sch Med - Estados Unidos Vanderbilt University Medical Center - Estados Unidos Wake Forest University School of Medicine - Estados Unidos |
| 19 | Sim, Xueling | - |
Natl Univ Singapore - Singapur
Natl Univ Hlth Syst - Singapur National University of Singapore - Singapur |
| 20 | Spracklen, Cassandra N. | Mujer |
Univ North Carolina Chapel Hill - Estados Unidos
Univ Massachusetts Amherst - Estados Unidos UNC School of Medicine - Estados Unidos |
| 21 | Zhang, Weihua | - |
Imperial Coll London - Reino Unido
London North West Healthcare NHS Trust - Reino Unido Ealing Hospital - Reino Unido |
| 22 | Preuss, Michael H. | Hombre |
Icahn Sch Med Mt Sinai - Estados Unidos
Icahn School of Medicine at Mount Sinai - Estados Unidos |
| 23 | Bottinger, Erwin P. | Hombre |
Icahn Sch Med Mt Sinai - Estados Unidos
Icahn School of Medicine at Mount Sinai - Estados Unidos |
| 24 | Nadkarni, Girish N. | - |
Icahn Sch Med Mt Sinai - Estados Unidos
Hasso Plattner Inst - Alemania Icahn School of Medicine at Mount Sinai - Estados Unidos Hasso-Plattner-Institut für Softwaresystemtechnik GmbH - Alemania |
| 25 | Loos, Ruth J.F. | Mujer |
Icahn Sch Med Mt Sinai - Estados Unidos
Icahn School of Medicine at Mount Sinai - Estados Unidos |
| 26 | Chen, Yii Der Ida | - |
Harbor UCLA Med Ctr - Estados Unidos
Harbor-UCLA Medical Center - Estados Unidos |
| 27 | Tan, Jingyi | - |
Harbor UCLA Med Ctr - Estados Unidos
Harbor-UCLA Medical Center - Estados Unidos |
| 28 | Ipp, Eli | - |
Harbor UCLA Med Ctr - Estados Unidos
The Lundquist Institute - Estados Unidos |
| 29 | Genter, Pauline | - |
Harbor UCLA Med Ctr - Estados Unidos
The Lundquist Institute - Estados Unidos |
| 30 | Emery, Leslie S. | - |
UNIV WASHINGTON - Estados Unidos
University of Washington - Estados Unidos |
| 31 | Louie, Tin | - |
UNIV WASHINGTON - Estados Unidos
University of Washington - Estados Unidos |
| 32 | Sofer, Tamar | - |
Harvard Univ - Estados Unidos
Harvard Med Sch - Estados Unidos Brigham & Womens Hosp - Estados Unidos Harvard University - Estados Unidos Harvard Medical School - Estados Unidos Brigham and Women's Hospital - Estados Unidos |
| 33 | Stilp, Adrienne M. | - |
UNIV WASHINGTON - Estados Unidos
University of Washington - Estados Unidos |
| 34 | Taylor, Kent D. | Hombre |
Harbor UCLA Med Ctr - Estados Unidos
Harbor-UCLA Medical Center - Estados Unidos |
| 35 | Xiang, Anny H. | - |
Kaiser Permanente Southern Calif - Estados Unidos
Kaiser Permanente - Estados Unidos |
| 36 | Buchanan, Thomas A. | - |
USC - Estados Unidos
Keck School of Medicine of USC - Estados Unidos |
| 37 | Roll, Kathryn | - |
Harbor UCLA Med Ctr - Estados Unidos
Harbor-UCLA Medical Center - Estados Unidos |
| 38 | Gao, Chuan | - |
Wake Forest Sch Med - Estados Unidos
Wake Forest University School of Medicine - Estados Unidos |
| 39 | Palmer, Nicholette D. | - |
Wake Forest Sch Med - Estados Unidos
Wake Forest University School of Medicine - Estados Unidos |
| 40 | Norris, Jill M. | - |
Univ Colorado Denver - Estados Unidos
University of Colorado Anschutz Medical Campus - Estados Unidos |
| 41 | Wagenknecht, Lynne E. | - |
Wake Forest Sch Med - Estados Unidos
Wake Forest University School of Medicine - Estados Unidos |
| 42 | Nousome, Darryl | - |
Univ Southern Calif - Estados Unidos
Keck School of Medicine of USC - Estados Unidos |
| 43 | Varma, Rohit | - |
CHA Hollywood Presbyterian Med Ctr - Estados Unidos
Hollywood Presbyterian Medical Center - Estados Unidos |
| 44 | McKean-Cowdin, Roberta | - |
Univ Southern Calif - Estados Unidos
Keck School of Medicine of USC - Estados Unidos |
| 45 | Guo, Xiuqing | - |
Harbor UCLA Med Ctr - Estados Unidos
Harbor-UCLA Medical Center - Estados Unidos |
| 46 | Hai, Yang | - |
Harbor UCLA Med Ctr - Estados Unidos
Harbor-UCLA Medical Center - Estados Unidos |
| 47 | Hsueh, Willa | - |
OHIO STATE UNIV - Estados Unidos
The Ohio State University Wexner Medical Center - Estados Unidos |
| 48 | Sandow, Kevin | - |
Harbor UCLA Med Ctr - Estados Unidos
Harbor-UCLA Medical Center - Estados Unidos |
| 49 | Parra, Esteban J. | Hombre |
Univ Toronto Mississauga - Canadá
University of Toronto - Canadá |
| 50 | Cruz, Miguel | Hombre |
Ctr Med Nacl Siglo Xxi - México
UMAE Hospital de Especialidades Centro Medico Nacional Siglo XXI - México |
| 51 | Valladares-Salgado, Adan | - |
Ctr Med Nacl Siglo Xxi - México
UMAE Hospital de Especialidades Centro Medico Nacional Siglo XXI - México |
| 52 | Wacher-Rodarte, Niels | - |
Ctr Med Nacl Siglo Xxi - México
UMAE Hospital de Especialidades Centro Medico Nacional Siglo XXI - México |
| 53 | Rotter, Jerome I. | Hombre |
Harbor UCLA Med Ctr - Estados Unidos
Harbor-UCLA Medical Center - Estados Unidos |
| 54 | Goodarzi, Mark O. | - |
Cedars Sinai Med Ctr - Estados Unidos
Cedars-Sinai Medical Center - Estados Unidos |
| 55 | Rich, Stephen S. | Hombre |
UNIV VIRGINIA - Estados Unidos
University of Virginia School of Medicine - Estados Unidos |
| 56 | Bertoni, Alain | - |
Wake Forest Sch Med - Estados Unidos
Wake Forest University School of Medicine - Estados Unidos |
| 57 | Raffel, Leslie J. | - |
UCI - Estados Unidos
UNC School of Medicine - Estados Unidos |
| 58 | Nadler, Jerry L. | - |
NEW YORK MED COLL - Estados Unidos
New York Medical college - Estados Unidos |
| 59 | Kandeel, Fouad R. | - |
City Hope Natl Med Ctr - Estados Unidos
City of Hope National Med Center - Estados Unidos |
| 60 | Duggirala, Ravindranath | - |
Univ Texas Rio Grande Valley - Estados Unidos
The University of Texas Rio Grande Valley - Estados Unidos |
| 61 | Blangero, J. | Hombre |
Univ Texas Rio Grande Valley - Estados Unidos
The University of Texas Rio Grande Valley - Estados Unidos |
| 62 | Lehman, Donna M. | - |
Univ Texas Hlth Sci Ctr San Antonio - Estados Unidos
Joe R. & Teresa Lozano Long School of Medicine - Estados Unidos |
| 63 | DeFronzo, Ralph A. | - |
Joe R. & Teresa Lozano Long School of Medicine - Estados Unidos
|
| 64 | Thameem, Farook | - |
Kuwait Univ - Kuwait
Kuwait University - Kuwait |
| 65 | Wang, Yujie | - |
Univ North Carolina Chapel Hill - Estados Unidos
UNC Gillings School of Global Public Health - Estados Unidos |
| 66 | Gahagan, Sheila | Mujer |
Univ Calif San Diego - Estados Unidos
University of California, San Diego - Estados Unidos |
| 67 | Blanco, Estela | - |
Pontificia Universidad Católica de Chile - Chile
|
| 68 | BURROWS-ARGOTE, RAQUEL DEL CARMEN | Mujer |
Universidad de Chile - Chile
|
| 69 | Huerta-Chagoya, Alicia | Mujer |
Consejo Nacl Ciencia & Tecnol CONACYT - México
Broad Inst Harvard & MIT - Estados Unidos MASSACHUSETTS GEN HOSP - Estados Unidos Instituto Nacional de la Nutrición Salvador Zubiran - México Broad Institute - Estados Unidos Massachusetts General Hospital - Estados Unidos |
| 70 | Florez, Jose C. | - |
Harvard Med Sch - Estados Unidos
Broad Inst Harvard & MIT - Estados Unidos MASSACHUSETTS GEN HOSP - Estados Unidos Harvard Medical School - Estados Unidos Broad Institute - Estados Unidos Massachusetts General Hospital - Estados Unidos |
| 71 | Tusie-Luna, Teresa | Mujer |
Univ Nacl Autonoma Mexico - México
Instituto Nacional de la Nutrición Salvador Zubiran - México |
| 72 | Gonzalez-Villalpando, Clicerio | - |
INST NACL SALUD PUBL - México
Instituto Nacional de Salud Pública. Tlalpan - México |
| 73 | Orozco, Lorena | Mujer |
Inst Nacl Med Genom - México
Instituto Nacional de Medicina Genómica - México |
| 74 | Haiman, Christopher | Hombre |
USC - Estados Unidos
Keck School of Medicine of USC - Estados Unidos |
| 75 | Hanis, Craig L. | - |
Univ Texas Hlth Sci Ctr Houston - Estados Unidos
UTHealth Houston School of Public Health - Estados Unidos |
| 76 | Rohde, Rebecca | Mujer |
Univ North Carolina Chapel Hill - Estados Unidos
UNC Gillings School of Global Public Health - Estados Unidos |
| 77 | Whitsel, Eric A. | - |
Univ North Carolina Chapel Hill - Estados Unidos
UNC Gillings School of Global Public Health - Estados Unidos UNC School of Medicine - Estados Unidos |
| 78 | Reiner, Alexander P. | Hombre |
UNIV WASHINGTON - Estados Unidos
Fred Hutchinson Canc Res Ctr - Estados Unidos University of Washington - Estados Unidos |
| 79 | Kooperberg, Charles | Hombre |
Fred Hutchinson Canc Res Ctr - Estados Unidos
|
| 80 | Li, Yun | - |
Univ North Carolina Chapel Hill - Estados Unidos
UNC School of Medicine - Estados Unidos |
| 81 | Duan, Qing | - |
Univ North Carolina Chapel Hill - Estados Unidos
UNC School of Medicine - Estados Unidos |
| 82 | Lee, Miryoung | - |
Univ Texas Hlth Sci Ctr Houston - Estados Unidos
UTHealth Houston School of Public Health - Estados Unidos |
| 83 | Correa-Burrows, Paulina | - |
Universidad de Chile - Chile
|
| 84 | Fried, Susan K. | - |
Icahn Sch Med Mt Sinai - Estados Unidos
Icahn School of Medicine at Mount Sinai - Estados Unidos |
| 85 | North, Kari E. | Mujer |
Univ North Carolina Chapel Hill - Estados Unidos
UNC Gillings School of Global Public Health - Estados Unidos |
| 86 | McCormick, Joseph B. | - |
UTHealth Houston School of Public Health - Estados Unidos
|
| 87 | Fisher-Hoch, Susan P. | - |
Univ Texas Hlth Sci Ctr Houston - Estados Unidos
UTHealth Houston School of Public Health - Estados Unidos |
| 88 | Gamazon, Eric R. | - |
Vanderbilt Univ - Estados Unidos
UNIV CAMBRIDGE - Reino Unido Vanderbilt University Medical Center - Estados Unidos MRC Epidemiology Unit - Reino Unido |
| 89 | Morris, Andrew P. | - |
UNIV MANCHESTER - Reino Unido
Faculty of Biology, Medicine and Health - Reino Unido |
| 90 | Mercader, Josep | Hombre |
Harvard Med Sch - Estados Unidos
Broad Inst Harvard & MIT - Estados Unidos MASSACHUSETTS GEN HOSP - Estados Unidos Harvard Medical School - Estados Unidos Broad Institute - Estados Unidos Massachusetts General Hospital - Estados Unidos |
| 91 | Highland, Heather M. | Mujer |
Univ North Carolina Chapel Hill - Estados Unidos
UNC Gillings School of Global Public Health - Estados Unidos |
| 92 | Anderson, Jennifer | Mujer |
Vanderbilt Univ - Estados Unidos
Vanderbilt University Medical Center - Estados Unidos |
| 93 | DIAMANTE Hispanic Latino Consortium | Corporación | |
| 94 | Global Hispanic Lipids Consortium | Corporación |
| Fuente |
|---|
| American Heart Association |
| National Human Genome Research Institute |
| American Diabetes Association |
| NHGRI |
| U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) |
| Agradecimiento |
|---|
| Acknowledgements for each participating study are listed in Supplementary Data 1. R01HL142302 partially supported J.E.B., K.E.N., and L.E.P.; J.M.M. is supported by American Diabetes Association grant #11-22-ICTSPM-16 and by NHGRI U01HG011723; R.J.F.L. is supported by R01DK110113, R01DK107786, R01HL142302, and R56HG010297; K.E.N. is supported primarily by 299 U01HG007416, with additional support provided via R01DK101855 and 15GRNT25880008; C.N.S. was supported by American Heart Association Postdoctoral Fellowships 15POST24470131 and 17POST33650016; M.B. is supported by DK062370. A.H.-C. is supported by the American Diabetes Association grant 11-23-PDF-35. Additional funding sources supporting each participating study are listed in Supplementary Data 1. |
| Acknowledgements for each participating study are listed in Supplementary Data . R01HL142302 partially supported J.E.B., K.E.N., and L.E.P.; J.M.M. is supported by American Diabetes Association grant #11-22-ICTSPM-16 and by NHGRI U01HG011723; R.J.F.L. is supported by R01DK110113, R01DK107786, R01HL142302, and R56HG010297; K.E.N. is supported primarily by 299 U01HG007416, with additional support provided via R01DK101855 and 15GRNT25880008; C.N.S. was supported by American Heart Association Postdoctoral Fellowships 15POST24470131 and 17POST33650016; M.B. is supported by DK062370. A.H.-C. is supported by the American Diabetes Association grant 11-23-PDF-35. Additional funding sources supporting each participating study are listed in Supplementary Data . |
