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Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample
| Indexado |
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| DOI | 10.1038/S41537-025-00578-1 | ||||
| Año | 2025 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
Cognitive impairment occurs at higher rates in individuals at clinical high risk (CHR) for psychosis relative to healthy peers, and it contributes unique variance to multivariate prediction models of transition to psychosis. Such impairment is considered a core biomarker of schizophrenia. Thus, cognition is a key domain measured in the Accelerating Medicines Partnership (R) program for Schizophrenia (AMP SCZ initiative). The aim of this paper is to describe the rationale, processes, considerations, and final harmonization of the cognitive battery used in AMP SCZ across the two data collection networks. This battery comprises tests of general intellect and specific cognitive domains. We estimate premorbid intelligence at baseline and measure current intelligence at baseline and 2 years. Eight tests from the Penn Computerized Neurocognitive Battery (PennCNB), which measure verbal learning and memory, sensorimotor ability, attention, emotion recognition, working memory, processing speed, verbal memory, visual memory, and motor speed are administered repeatedly at baseline, and four follow-up timepoints over 2 years.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Allott, Kelly | - |
Orygen - Australia
Univ Melbourne - Australia ORYGEN Youth Health - Australia Centre for Youth Mental Health - Australia |
| 2 | Yassin, Walid | - |
Massachusetts Mental Hlth Ctr - Estados Unidos
Harvard Med Sch - Estados Unidos |
| 3 | Alameda, Luis | - |
Lausanne Univ Hosp CHUV - Suiza
Univ Lausanne - Suiza Kings Coll London - Reino Unido Centre Hospitalier Universitaire Vaudois - Suiza |
| 4 | Billah, Tashrif | - |
Harvard Med Sch - Estados Unidos
Harvard Medical School - Estados Unidos |
| 5 | Borders, Owen | - |
Harvard Med Sch - Estados Unidos
Harvard Medical School - Estados Unidos |
| 6 | Buccilli, Kate | - |
Orygen - Australia
Univ Melbourne - Australia ORYGEN Youth Health - Australia Centre for Youth Mental Health - Australia |
| 7 | Carrion, Ricardo E. | - |
Donald & Barbara Zucker Sch Med - Estados Unidos
Feinstein Inst Med Res - Estados Unidos Donald and Barbara Zucker School of Medicine at Hofstra/Northwell - Estados Unidos Feinstein Institute for Medical Research - Estados Unidos |
| 8 | Castillo-Passi, Rolando I. | - |
Universidad de Chile - Chile
Universidad del Desarrollo - Chile |
| 9 | Cho, Kang-Ik K. | - |
Harvard Med Sch - Estados Unidos
Harvard Medical School - Estados Unidos |
| 10 | Chin, Kota | - |
Harvard Med Sch - Estados Unidos
Harvard Medical School - Estados Unidos |
| 11 | Coleman, Michael J. | - |
Harvard Med Sch - Estados Unidos
Harvard Medical School - Estados Unidos |
| 12 | Colton, Beau-Luke | - |
Orygen - Australia
Univ Melbourne - Australia ORYGEN Youth Health - Australia Centre for Youth Mental Health - Australia |
| 13 | Corral, Sebastian | - |
Universidad de Chile - Chile
Universidad de la Serena - Chile |
| 14 | Dwyer, Dominic | - |
Orygen - Australia
Univ Melbourne - Australia ORYGEN Youth Health - Australia Centre for Youth Mental Health - Australia |
| 15 | Gundersen, Kristina Ballestad | - |
Copenhagen Univ Hosp - Dinamarca
Univ Copenhagen - Dinamarca Københavns Universitet - Dinamarca |
| 16 | Gur, Ruben C. | - |
UNIV PENN - Estados Unidos
University of Pennsylvania Perelman School of Medicine - Estados Unidos |
| 17 | Hoftman, Gil D. | - |
Northwell Hlth - Estados Unidos
Northwell Health System - Estados Unidos |
| 18 | Jacobs, Grace R. | - |
Harvard Med Sch - Estados Unidos
Harvard Medical School - Estados Unidos |
| 19 | Kelly, Sinead | - |
Harvard Med Sch - Estados Unidos
Harvard Medical School - Estados Unidos |
| 20 | Lewandowski, Kathryn E. | - |
McLean Hosp - Estados Unidos
Harvard Med Sch - Estados Unidos McLean Hospital - Estados Unidos Harvard Medical School - Estados Unidos |
| 21 | Marcy, Patricia J. | - |
Northwell Hlth - Estados Unidos
Northwell Health System - Estados Unidos |
| 22 | Matneja, Priya | - |
Northwell Hlth - Estados Unidos
Northwell Health System - Estados Unidos |
| 23 | Mclaughlin, Danielle | - |
Northwell Hlth - Estados Unidos
Northwell Health System - Estados Unidos |
| 24 | Nunez, Angela R. | - |
YALE UNIV - Estados Unidos
Connecticut Mental Hlth Ctr - Estados Unidos Yale School of Medicine - Estados Unidos |
| 25 | Parsa, Setari | - |
Massachusetts Mental Hlth Ctr - Estados Unidos
Harvard Med Sch - Estados Unidos |
| 26 | Penzel, Nora | - |
Harvard Med Sch - Estados Unidos
MASSACHUSETTS GEN HOSP - Estados Unidos Massachusetts General Hospital - Estados Unidos |
| 27 | Ray, Susan | - |
Northwell Hlth - Estados Unidos
Northwell Health System - Estados Unidos |
| 28 | Reinen, Jenna M. | - |
IBM Res - Estados Unidos
TJ Watson Res Lab - Estados Unidos IBM Research - Estados Unidos Watson Research Laboratory - Estados Unidos |
| 29 | Ruparel, Kosha | - |
UNIV PENN - Estados Unidos
University of Pennsylvania Perelman School of Medicine - Estados Unidos |
| 30 | Sand, Michael S. | - |
S2 Consulting LLC - Estados Unidos
|
| 31 | Santorelli, Gennarina | - |
Massachusetts Mental Hlth Ctr - Estados Unidos
Harvard Med Sch - Estados Unidos |
| 32 | Seitz-Holland, Johanna | - |
Harvard Med Sch - Estados Unidos
MASSACHUSETTS GEN HOSP - Estados Unidos Harvard Medical School - Estados Unidos Massachusetts General Hospital - Estados Unidos |
| 33 | Spark, Jessica | - |
Orygen - Australia
Univ Melbourne - Australia Harvard Med Sch - Estados Unidos ORYGEN Youth Health - Australia Centre for Youth Mental Health - Australia |
| 34 | Tamayo, Zailyn | - |
YALE UNIV - Estados Unidos
Yale School of Medicine - Estados Unidos |
| 35 | Thompson, Andrew | - |
Orygen - Australia
Univ Melbourne - Australia Univ Warwick - Reino Unido ORYGEN Youth Health - Australia Centre for Youth Mental Health - Australia Warwick Medical School - Reino Unido |
| 36 | Tod, Sophie | - |
Orygen - Australia
Univ Melbourne - Australia ORYGEN Youth Health - Australia Centre for Youth Mental Health - Australia |
| 37 | Wannan, Cassandra | - |
Orygen - Australia
Univ Melbourne - Australia ORYGEN Youth Health - Australia Centre for Youth Mental Health - Australia |
| 38 | Wickham, Alana | - |
Harvard Med Sch - Estados Unidos
Harvard Medical School - Estados Unidos |
| 39 | Wood, Stephen J. | - |
Orygen - Australia
Univ Melbourne - Australia Univ Birmingham - Reino Unido ORYGEN Youth Health - Australia Centre for Youth Mental Health - Australia University of Birmingham - Reino Unido |
| 40 | Zoupou, Eirini | - |
UNIV PENN - Estados Unidos
University of Pennsylvania Perelman School of Medicine - Estados Unidos |
| 41 | Addington, Jean | - |
Univ Calgary - Canadá
Hotchkiss Brain Institute - Canadá |
| 42 | Anticevic, Alan | - |
YALE UNIV - Estados Unidos
Yale School of Medicine - Estados Unidos |
| 43 | Arango, Celso | - |
UNIV COMPLUTENSE - España
Instituto de Investigación Sanitaria Gregorio Marañón - España |
| 44 | Breitborde, Nicholas J. K. | - |
OHIO STATE UNIV - Estados Unidos
The Ohio State University - Estados Unidos |
| 45 | Broome, Matthew R. | - |
Univ Birmingham - Reino Unido
Birmingham Womens & Childrens NHS Fdn Trust - Reino Unido University of Birmingham - Reino Unido |
| 46 | Cadenhead, Kristin S. | - |
Univ Calif San Diego - Estados Unidos
University of California, San Diego - Estados Unidos |
| 47 | Calkins, Monica E. | - |
UNIV PENN - Estados Unidos
University of Pennsylvania Perelman School of Medicine - Estados Unidos |
| 48 | Chen, Eric Yu Hai | - |
Univ Hong Kong - China
UNIV OXFORD - Reino Unido The University of Hong Kong - Hong Kong University of Oxford Medical Sciences Division - Reino Unido |
| 49 | Choi, Jimmy | - |
Hartford Hosp - Estados Unidos
Olin Neuropsychiatry Research Center - Estados Unidos |
| 50 | Conus, Philippe | - |
Lausanne Univ Hosp CHUV - Suiza
Univ Lausanne - Suiza Centre Hospitalier Universitaire Vaudois - Suiza |
| 51 | Corcoran, Cheryl M. | - |
Icahn Sch Med Mt Sinai - Estados Unidos
Icahn School of Medicine at Mount Sinai - Estados Unidos |
| 52 | Cornblatt, Barbara A. | - |
Donald & Barbara Zucker Sch Med - Estados Unidos
Feinstein Inst Med Res - Estados Unidos Donald and Barbara Zucker School of Medicine at Hofstra/Northwell - Estados Unidos Feinstein Institute for Medical Research - Estados Unidos |
| 53 | Ellman, Lauren M. | - |
Temple Univ - Estados Unidos
Temple University - Estados Unidos |
| 54 | Fusar-Poli, Paolo | - |
Kings Coll London - Reino Unido
Univ Pavia - Italia Università degli Studi di Pavia - Italia |
| 55 | Gaspar, Pablo A. | - |
Feinstein Inst Med Res - Estados Unidos
Universidad de Chile - Chile Feinstein Institute for Medical Research - Estados Unidos |
| 56 | Gerber, Carla | - |
UNIV OREGON - Estados Unidos
Oregon Res Inst - Estados Unidos University of Oregon - Estados Unidos Oregon Research Institute - Estados Unidos |
| 57 | Glenthoj, Louise Birkedal | - |
Copenhagen Univ Hosp - Dinamarca
Univ Copenhagen - Dinamarca Københavns Universitet - Dinamarca |
| 58 | Horton, Leslie E. | - |
Univ Pittsburgh - Estados Unidos
University of Pittsburgh School of Medicine - Estados Unidos |
| 59 | Hui, Christy Lai Ming | - |
Univ Hong Kong - China
The University of Hong Kong - Hong Kong |
| 60 | Kambeitz, Joseph | - |
Univ Cologne - Alemania
Univ Hosp Cologne - Alemania Medizinische Fakultät - Alemania |
| 61 | Kambeitz-Ilankovic, Lana | - |
Univ Cologne - Alemania
Univ Hosp Cologne - Alemania Ludwig Maximilian Univ Munich - Alemania Medizinische Fakultät - Alemania Klinikum der Universität München - Alemania |
| 62 | Keshavan, Matcheri | - |
Massachusetts Mental Hlth Ctr - Estados Unidos
Harvard Med Sch - Estados Unidos |
| 63 | Kim, Sung-Wan | - |
Chonnam Natl Univ - Corea del Sur
Gwangju Bukgu Mental Hlth Ctr - Corea del Sur Chonnam National University Medical School - Corea del Sur Bukgu Mental Health Center - Corea del Sur |
| 64 | Koutsouleris, Nikolaos | - |
Kings Coll London - Reino Unido
Ludwig Maximilian Univ Munich - Alemania Klinikum der Universität München - Alemania |
| 65 | Kwon, Jun Soo | - |
Seoul Natl Univ - Corea del Sur
Seoul Natl Univ Hosp - Corea del Sur Seoul National University College of Medicine - Corea del Sur Seoul National University Hospital - Corea del Sur |
| 66 | Langbein, Kerstin | - |
Jena Univ Hosp - Alemania
Universitätsklinikum Jena und Medizinische Fakultät - Alemania |
| 67 | Mamah, Daniel | - |
WASHINGTON UNIV - Estados Unidos
Washington University School of Medicine in St. Louis - Estados Unidos |
| 68 | Diaz-Caneja, Covadonga M. | - |
UNIV COMPLUTENSE - España
Instituto de Investigación Sanitaria Gregorio Marañón - España |
| 69 | Mamah, Daniel | - |
UNIV CALIF SAN FRANCISCO - Estados Unidos
Vet Affairs San Francisco Hlth Care Syst - Estados Unidos UCSF School of Medicine - Estados Unidos San Francisco VA Health Care System - Estados Unidos |
| 70 | Mittal, Vijay A. | - |
NORTHWESTERN UNIV - Estados Unidos
|
| 71 | Nordentoft, Merete | - |
Univ Copenhagen - Dinamarca
Copenhagen Univ Hosp - Dinamarca Københavns Universitet - Dinamarca Copenhagen University Hospital - Dinamarca |
| 72 | Pearlson, Godfrey D. | - |
Hartford Hosp - Estados Unidos
Yale Sch Med - Estados Unidos Olin Neuropsychiatry Research Center - Estados Unidos Yale School of Medicine - Estados Unidos |
| 73 | Perkins, Diana O. | - |
Univ North Carolina - Estados Unidos
UCSF School of Medicine - Estados Unidos |
| 74 | Perez, Jesus | - |
Cambridgeshire & Peterborough NHS Fdn Trust - Reino Unido
Univ Hosp Salamanca - España Universidad de Salamanca - España |
| 75 | Powers, Albert R. | - |
Connecticut Mental Hlth Ctr - Estados Unidos
Yale Sch Med - Estados Unidos Yale School of Medicine - Estados Unidos |
| 76 | Rogers, Jack | - |
Univ Birmingham - Reino Unido
University of Birmingham - Reino Unido |
| 77 | Sabb, Fred W. | - |
UNIV OREGON - Estados Unidos
University of Oregon - Estados Unidos |
| 78 | Schiffman, Jason | - |
Univ Calif Irvine - Estados Unidos
University of California, Irvine - Estados Unidos |
| 79 | Shah, Jai L. | - |
Douglas Hosp - Canadá
MCGILL UNIV - Canadá Le Centre de Recherche Douglas - Canadá UCSF School of Medicine - Canadá |
| 80 | Silverstein, Steven M. | - |
Univ Rochester - Estados Unidos
University of Rochester Medical Center - Estados Unidos |
| 81 | Smesny, Stefan | - |
Jena Univ Hosp - Alemania
Universitätsklinikum Jena und Medizinische Fakultät - Alemania |
| 82 | Strauss, Gregory P. | - |
Univ Georgia - Estados Unidos
Franklin College of Arts and Sciences - Estados Unidos |
| 83 | Thompson, Judy L. | - |
Univ Rochester - Estados Unidos
University of Rochester Medical Center - Estados Unidos |
| 84 | Upthegrove, Rachel | - |
Univ Birmingham - Reino Unido
UNIV OXFORD - Reino Unido University of Birmingham - Reino Unido University of Oxford Medical Sciences Division - Reino Unido |
| 85 | Verma, Swapna K. | - |
Inst Mental Hlth - Singapur
Duke NUS Med Sch - Singapur Singapore Institute of Mental Health - Singapur Duke-NUS Medical School - Singapur |
| 86 | Wang, Jijun | - |
Shanghai Jiao Tong Univ - China
Shanghai Mental Health Center - China |
| 87 | Wolf, Daniel H. | - |
UNIV PENN - Estados Unidos
University of Pennsylvania Perelman School of Medicine - Estados Unidos |
| 88 | Pasternak, Ofer | - |
Harvard Med Sch - Estados Unidos
MASSACHUSETTS GEN HOSP - Estados Unidos Harvard Medical School - Estados Unidos Massachusetts General Hospital - Estados Unidos |
| 89 | Bouix, Sylvain | - |
Ecole Technol Super - Canadá
École de Technologie Supérieure - Canadá |
| 90 | Mcgorry, Patrick D. | - |
Orygen - Australia
Univ Melbourne - Australia ORYGEN Youth Health - Australia Centre for Youth Mental Health - Australia |
| 91 | Kane, John M. | - |
Donald & Barbara Zucker Sch Med - Estados Unidos
Feinstein Inst Med Res - Estados Unidos Donald and Barbara Zucker School of Medicine at Hofstra/Northwell - Estados Unidos Feinstein Institute for Medical Research - Estados Unidos |
| 92 | Kahn, Rene S. | - |
Icahn Sch Med Mt Sinai - Estados Unidos
Icahn School of Medicine at Mount Sinai - Estados Unidos |
| 93 | Bearden, Carrie E. | - |
UNIV CALIF LOS ANGELES - Estados Unidos
Jane & Terry Semel Institute for Neuroscience & Human Behavior - Estados Unidos University of California, Los Angeles - Estados Unidos |
| 94 | Shenton, Martha E. | - |
Harvard Med Sch - Estados Unidos
MASSACHUSETTS GEN HOSP - Estados Unidos Harvard Medical School - Estados Unidos Massachusetts General Hospital - Estados Unidos |
| 95 | Woods, Scott W. | - |
Connecticut Mental Hlth Ctr - Estados Unidos
Yale Sch Med - Estados Unidos Yale School of Medicine - Estados Unidos |
| 96 | Nelson, Barnaby | - |
Orygen - Australia
Univ Melbourne - Australia ORYGEN Youth Health - Australia Centre for Youth Mental Health - Australia |
| 97 | Accelerating Med Partnership Schizophrenia AMP SCZ, William S. | - | |
| 98 | Stone, William S. | - |
Massachusetts Mental Hlth Ctr - Estados Unidos
Harvard Med Sch - Estados Unidos |
| Fuente |
|---|
| National Institutes of Health |
| Ministerio de Ciencia e Innovación |
| Instituto de Salud Carlos III |
| Wellcome Trust |
| National Institute of Mental Health |
| Wellcome |
| NIMH |
| Angelini Pharma |
| U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) |
| Johnson & Johnson Innovative Medicine |
| Agradecimiento |
|---|
| The Accelerating Medicines Partnership (R) Schizophrenia (AMP SCZ) is a public-private partnership managed by the Foundation for the National Institutes of Health. The AMP SCZ research program is supported by contributions from the AMP SCZ public and private partners, including NIMH (U24MH124629, U01MH124631, and U01MH124639) and Wellcome (220664/Z/20/Z and 220664/A/20/Z). A full list of AMP SCZ members and affiliations can be found at https://www.ampscz.org/members/ and within the Supplementary File. |
| The authors declare the following competing interests: K.A. is on the Australian Cognitive Impairment Associated with Schizophrenia Advisory Board for Boehringer Ingelheim and receives honorary funds; D.D. has received honorary funds for one educational seminar for CSL Sequiris; A.A. is a cofounder, serves as a member of the Board of Directors, as a scientific adviser, and holds equity in Manifest Technologies, Inc.; and is a coinventor on the following patent: Anticevic A, Murray JD, Ji JL: Systems and Methods for NeuroBehavioral Relationships in Dimensional Geometric Embedding, PCT International Application No. PCT/US2119/022110, filed Mar 13, 2019; E.C. has received speaker fees at non-promotional educational events; P.F.P. has received research funds or personal fees from Lundbeck, Angelini, Menarini, Sunovion, Boehringer Ingelheim, Proxymm Science, Otsuka, outside the current study; J.K. has received speaking or consulting fees from Janssen, Boehringer Ingelheim, ROVI and Lundbeck; C.D.C. has received grant support from Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation and honoraria or travel support from Angelini, Janssen, and Viatris; R.U. has received speaker fees at non promotional educational event: Otsuka: Consultancy for Viatris and Springer HealtCCare. Honorary General Secretary British Association for Psychopharmacology (unpaid); JMK is a consultant to or receives honoraria and/or travel support and/or speakers bureau: Alkermes, Allergan, Boehringer-Ingelheim, Cerevel, Dainippon Sumitomo, H. Lundbeck, HealthRhythms, HLS Therapeutics, Indivior, Intracellular Therapies, Janssen Pharmaceutical, Johnson & Johnson, Karuna Therapeutics/Bristol Meyer-Squibb, LB Pharmaceuticals, Mapi, Maplight, Merck, Minerva, Neurocrine, Newron, Novartis, NW PharmaTech, Otsuka, Roche, Saladax, Sunovion, Teva. Advisory Boards: Alkermes, Boehringer-Ingelheim, Cerevel, Click Therapeutics, Karuna/BMS, Lundbeck, Merck, Newron, Novartis, Otsuka, Sumitomo, Teva, Terran Grant Support: Lundbeck, Janssen, Otsuka, Sunovion Shareholder: Cerevel (public/stock), HealthRhythms (private/stock options), Karuna/BMS (public), LB Pharmaceuticals, Inc. (private/stock options), North Shore Therapeutics (private/stock), Vanguard Research Group (private/40% owner) Receives Royalties: Up to Date; RSK provides consulting to Alkermes, Boehringer-Ingelheim; S.W.W. has received speaking fees from the American Psychiatric Association and from Medscape Features. He has been granted US patent no. 8492418 B2 for a method of treating prodromal schizophrenia with glycine agonists. He owns stock in NW PharmaTech; C.A. has been a consultant to or has received honoraria or grants from Acadia, Angelini, Biogen, Boehringer, Gedeon Richter, Janssen Cilag, Lundbeck, Medscape, Menarini, Minerva, Otsuka, Pfizer, Roche, Sage, Servier, Shire, Schering Plough, Sumitomo Dainippon Pharma, Sunovion and Takeda; G.D.H. has been a consultant for Bristol Myers Squibb; P.J.M. has been a consultant for Otsuka and TEVA; and Z.T. has been a consult for Manifest Technologies. All other authors report no competing interests. C.M.C. is an Associate Editor of Schizophrenia. |
| The Accelerating Medicines Partnership\u00AE Schizophrenia (AMP SCZ) is a public-private partnership managed by the Foundation for the National Institutes of Health. The AMP SCZ research program is supported by contributions from the AMP SCZ public and private partners, including NIMH (U24MH124629, U01MH124631, and U01MH124639) and Wellcome (220664/Z/20/Z and 220664/A/20/Z). A full list of AMP SCZ members and affiliations can be found at https://www.ampscz.org/members/ and within the Supplementary File. |
