Medium- and high-power drive applications have grown since the past decade as the most common solution for high demanding industrial processes. Multilevel converters, in particular the three-level neutral point clamped (3L-NPC) topology driving medium-voltage induction machines, has become the most commonly adopted solution. In this context, several AC drive control schemes are suitable, such as scalar control (SC), field-oriented control (FOC), model predictive control (MPC), and direct torque control (DTC). Each of these control strategies exhibit a particular operational profile which affects the switching pattern of the converter semiconductors, thus conditioning the switching and conducting losses of these power devices. This work presents a comparison of the conduction and switching losses between different drives control schemes, such as scalar control, field-oriented control, direct torque control, and model predictive control, analyzing their impact on thermal efficiency in a 3L-NPC multilevel converter, under different loading operational conditions. This analysis allows for choosing the most suitable control strategy and switching frequency for a given operational profile.