The impact of chronic non-cancer pain on individuals is complex, multidimensional, and with healthcare needs that challenge fragmented healthcare systems. There have been significant advances in generating scientific evidence, ministerial guidelines, and even laws in Chile. However, there is still a considerable gap that remains in the implementation in clinical practice. Despite this, clinical teams have implemented three pilot programs in different countries. This perspective discusses these pilots, their implementation process, acquired knowledge, and the challenge of advancing toward scaling up.