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Genome-wide association study of long COVID
| Indexado |
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| DOI | 10.1038/S41588-025-02100-W | ||
| Año | 2025 | ||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in long coronavirus disease (COVID), typically manifesting as fatigue, pulmonary symptoms and cognitive dysfunction. The biological mechanisms behind long COVID remain unclear. We performed a genome-wide association study for long COVID including up to 6,450 long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We discovered an association of FOXP4 with long COVID, independent of its previously identified association with severe COVID-19. The signal was replicated in 9,500 long COVID cases and 798,835 population controls. Given the transcription factor FOXP4's role in lung physiology and pathology, our findings highlight the importance of lung function in the pathophysiology of long COVID.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Lammi, Vilma | - |
Univ Helsinki - Finlandia
|
| 2 | Nakanishi, Tomoko | - |
Univ Helsinki - Finlandia
MCGILL UNIV - Canadá KYOTO UNIV - Japón Univ Tokyo - Japón Japan Soc Promot Sci - Japón |
| 3 | Jones, Samuel E. | - |
Univ Helsinki - Finlandia
|
| 4 | Andrews, Shea J. | - |
UNIV CALIF SAN FRANCISCO - Estados Unidos
|
| 5 | Karjalainen, Juha | - |
Univ Helsinki - Finlandia
Broad Inst Harvard & MIT - Estados Unidos MASSACHUSETTS GEN HOSP - Estados Unidos |
| 6 | Cortes, Beatriz | - |
Germans Trias & Pujol Res Inst IGTP - España
Grp REcerca Impacte Malalties Cron & Seves Trajec - España |
| 7 | O'Brien, Heath E. | - |
Sano Genet Ltd - Reino Unido
|
| 8 | Ochoa-Guzman, Ana | - |
Inst Nacl Ciencias Med Nutr & Salvador Zubiran - México
|
| 9 | Fulton-Howard, Brian E. | - |
Icahn Sch Med Mt Sinai - Estados Unidos
|
| 10 | Broberg, Martin | - |
Univ Helsinki - Finlandia
|
| 11 | Haapaniemi, Hele H. | - |
Univ Helsinki - Finlandia
|
| 12 | Kanai, Masahiro | Hombre |
Broad Inst - Estados Unidos
Harvard Med Sch - Estados Unidos |
| 13 | Pirinen, Matti | - |
Univ Helsinki - Finlandia
|
| 14 | Schmidt, Axel | - |
UNIV BONN - Alemania
Univ Hosp Bonn - Alemania |
| 15 | Mitchell, Ruth E. | Mujer |
Univ Bristol - Reino Unido
|
| 16 | Mousas, Abdou | - |
Univ Ioannina - Grecia
|
| 17 | Mangino, Massimo | Hombre |
Kings Coll London - Reino Unido
|
| 18 | Huerta-Chagoya, Alicia | Mujer |
Broad Inst MIT & Harvard - Estados Unidos
MASSACHUSETTS GEN HOSP - Estados Unidos Univ Nacl Autonoma Mexico - México Inst Nacl Ciencias Med & Nutr Salvador Zubiran - México |
| 19 | Sinnott-Armstrong, Nasa | - |
Fred Hutchinson Canc Ctr - Estados Unidos
UNIV WASHINGTON - Estados Unidos Univ Helsinki - Finlandia |
| 20 | Cirulli, Elizabeth T. | - |
Helix - Estados Unidos
|
| 21 | Vaudel, Marc | - |
Univ Bergen - Noruega
Norwegian Inst Publ Hlth - Noruega |
| 22 | Kwong, Alex S. F. | - |
UNIV EDINBURGH - Reino Unido
|
| 23 | Maiti, Amit K. | - |
Mydnavar - Estados Unidos
|
| 24 | Marttila, Minttu M. | - |
Univ Helsinki - Finlandia
Helsinki Univ Cent Hosp - Finlandia |
| 25 | Posner, Daniel C. | - |
VA Boston Healthcare Syst - Estados Unidos
|
| 26 | Rodriguez, Alexis A. | - |
Argonne Natl Lab - Estados Unidos
|
| 27 | Batini, Chiara | - |
Univ Leicester - Reino Unido
Univ Hosp Leicester NHS Trust - Reino Unido |
| 28 | Minnai, Francesca | - |
CNR - Italia
Univ Milan - Italia |
| 29 | Dearman, Anna R. | - |
Univ Essex - Reino Unido
|
| 30 | Warmerdam, C. A. Robert | - |
Univ Groningen - Países Bajos
|
| 31 | Sequeros, Celia B. | - |
Univ Copenhagen - Dinamarca
|
| 32 | Winkler, Thomas W. | Hombre |
Univ Regensburg - Alemania
|
| 33 | Jordan, Daniel M. | - |
Icahn Sch Med Mt Sinai - Estados Unidos
|
| 34 | Rescenko, Raimonds | - |
Latvian Biomed Res & Study Ctr - Letonia
|
| 35 | Miano, Lorenzo | - |
Univ Milan - Italia
|
| 36 | Lane, Jacqueline M. | - |
Brigham & Womens Hosp - Estados Unidos
MASSACHUSETTS GEN HOSP - Estados Unidos Broad Inst - Estados Unidos |
| 37 | Chung, Ryan K. | - |
UNIV CALIF BERKELEY - Estados Unidos
|
| 38 | Guillen-Guio, Beatriz | - |
Univ Leicester - Reino Unido
|
| 39 | Leavy, Olivia C. | - |
Univ Leicester - Reino Unido
|
| 40 | Carvajal-Silva, Laura | - |
Universidad de Chile - Chile
|
| 41 | Aguilar-Valdes, Kevin | - |
Universidad de Chile - Chile
|
| 42 | Frangione, Erika | - |
MT SINAI HOSP - Canadá
|
| 43 | Guare, Lindsay | - |
UNIV PENN - Estados Unidos
|
| 44 | Vergasova, Ekaterina | - |
Genotek Ltd - Rusia
|
| 45 | Marouli, Eirini | Mujer |
Queen Mary Univ London - Reino Unido
|
| 46 | Striano, Pasquale | - |
IRCCS G Gaslini - Italia
|
| 47 | Zainulabid, Ummu Afeera | - |
Int Islamic Univ Malaysia - Malasia
|
| 48 | Kumar, Ashutosh | - |
All India Inst Med Sci - India
|
| 49 | Ahmad, Hajar Fauzan | - |
Univ Malaysia Pahang Sultan Abdullah - Malasia
|
| 50 | Edahiro, Ryuya | - |
Osaka Univ - Japón
|
| 51 | Azekawa, Shuhei | - |
Keio Univ - Japón
Nagoya Univ - Japón |
| 52 | Luoh, Shiuh-Wen | - |
VA Portland Hlth Care Syst - Estados Unidos
Oregon Hlth & Sci Univ - Estados Unidos |
| 53 | Erikstrup, Christian | - |
Aarhus Univ Hosp - Dinamarca
|
| 54 | Pedersen, Ole B. V. | - |
Zealand Univ Hosp Koge - Dinamarca
|
| 55 | Lerner-Ellis, Jordan | - |
UNIV TORONTO - Canadá
Sinai Hlth - Canadá |
| 56 | Colombo, Alicia | - |
Universidad de Chile - Chile
Hosp Clin Univ Chile - Chile |
| 57 | Grzymski, Joseph J. | - |
Univ Nevada Reno - Estados Unidos
|
| 58 | Ishii, Makoto | - |
Keio Univ - Japón
Nagoya Univ - Japón |
| 59 | Okada, Yukinori | Hombre |
Univ Leicester - Reino Unido
RIKEN Ctr Integrat Med Sci - Japón Osaka Univ - Japón |
| 60 | Beckmann, Noam D. | - |
Univ Milan - Italia
Icahn Sch Med Mt Sinai - Estados Unidos |
| 61 | Kumari, Meena | Mujer |
Univ Essex - Reino Unido
|
| 62 | Wagner, Ralf | - |
Univ Regensburg - Alemania
Univ Hosp Regensburg - Alemania |
| 63 | Heid, Iris M. | Mujer |
Univ Regensburg - Alemania
|
| 64 | John, Catherine | - |
Univ Leicester - Reino Unido
Glenfield Hosp - Reino Unido |
| 65 | Short, Patrick J. | - |
Sano Genet Ltd - Reino Unido
|
| 66 | Magnus, Per | - |
Norwegian Inst Publ Hlth - Noruega
|
| 67 | Ansone, Laura | - |
Latvian Biomed Res & Study Ctr - Letonia
|
| 68 | Valenti, Luca V. C. | - |
Univ Milan - Italia
Fdn IRCCS Ca Granda Osped Maggiore Policlin - Italia |
| 69 | Lee, Sulggi A. | - |
UNIV CALIF SAN FRANCISCO - Estados Unidos
|
| 70 | Wain, Louise V. | Mujer |
Univ Leicester - Reino Unido
|
| 71 | Verdugo, Ricardo A. | - |
Universidad de Chile - Chile
Universidad de Talca - Chile |
| 72 | Banasik, Karina | - |
Univ Copenhagen - Dinamarca
|
| 73 | Geller, Frank | - |
Statens Serum Inst - Dinamarca
|
| 74 | Franke, Lude H. | - |
Univ Groningen - Países Bajos
|
| 75 | Rakitko, Alexander | - |
Genotek Ltd - Rusia
|
| 76 | Duncan, Emma L. | - |
Guys & St Thomas NHS Fdn Trust - Reino Unido
Kings Coll London - Reino Unido |
| 77 | Renieri, Alessandra | Mujer |
Univ Siena - Italia
Azienda Osped Univ Senese - Italia |
| 78 | Tsilidis, Konstantinos K. | - |
Imperial Coll London - Reino Unido
|
| 79 | de Cida, Rafael | - |
Germans Trias & Pujol Res Inst IGTP - España
Grp REcerca Impacte Malalties Cron & Seves Trajec - España |
| 80 | Niavarani, Ahmadreza | - |
Univ Tehran Med Sci - Iran
|
| 81 | Abner, Erik | - |
Univ Tartu - Estonia
|
| 82 | Tusie-Luna, Teresa | - |
Univ Nacl Autonoma Mexico - México
Inst Nacl Ciencias Med & Nutr Salvador - México |
| 83 | Verma, Shefali S. | - |
UNIV PENN - Estados Unidos
|
| 84 | Smith, George Davey | - |
Univ Bristol - Reino Unido
|
| 85 | Timpson, Nicholas J. | Hombre |
Univ Bristol - Reino Unido
|
| 86 | Madduri, Ravi K. | - |
Argonne Natl Lab - Estados Unidos
|
| 87 | Choa, Kelly | - |
Harvard Med Sch - Estados Unidos
|
| 88 | Daly, Mark J. | - |
Broad Inst - Estados Unidos
Harvard Med Sch - Estados Unidos |
| 89 | Ganna, Andrea | - |
Broad Inst - Estados Unidos
Harvard Med Sch - Estados Unidos |
| 90 | Schulte, Eva C. | - |
UNIV MUNICH - Alemania
UNIV BONN - Alemania Tech Univ Munich Helmholtz Munich - Alemania |
| 91 | Richards, J. Brent | - |
MCGILL UNIV - Canadá
Kings Coll London - Reino Unido 5 Prime Sci Inc - Canadá |
| 92 | Ludwig, Kerstin U. | - |
UNIV BONN - Alemania
Univ Hosp Bonn - Alemania |
| 93 | Marks-Hultstroem, Michael | - |
5 Prime Sci Inc - Canadá
MCGILL UNIV - Canadá UPPSALA UNIV - Suecia |
| 94 | Zeberg, Hugo | - |
Max Planck Inst Evolutionary Anthropol - Alemania
Karolinska Inst - Suecia |
| 95 | Ollila, Hanna M. | - |
Univ Helsinki - Finlandia
MASSACHUSETTS GEN HOSP - Estados Unidos Harvard Med Sch - Estados Unidos Broad Inst MIT & Harvard - Estados Unidos |
| 96 | Long Covid Host Genetics Initiative | Corporación | |
| 97 | FinnGen | Corporación | |
| 98 | Va Million Vet Program | Corporación | |
| 99 | MexGen-Covid Initiative | Corporación | |
| 100 | DBDS Genomic Consortium | Corporación | |
| 101 | GEN-COVID Multictr Study | Corporación | |
| 102 | PHOSP-COVID Collaborative Grp | Corporación | |
| 103 | GENCOV Study | Corporación | |
| 104 | Estonian Biobank Research Team | Corporación |
| Fuente |
|---|
| We are grateful for the support from the Academy of Finland (#353812), the NIH (R01AI170850), and the EU. This project has received funding from the European Union's Horizon Europe research and innovation programme under grant agreement No 101057553. This |
| Agradecimiento |
|---|
| We are extremely grateful to all the participants, healthcare professionals, interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers and everyone participating in making possible the collection and analysis of datasets contributing to this study. We acknowledge the funding and research infrastructure support in Supplementary Note (see also the full Long COVID HGI author information in Supplementary Table 2). |
