Background: Multiple sclerosis (MS) is a degenerative disease affecting the central nervous system, significantly impacting quality of life. Relapsing-remitting MS (RRMS) is the most common subtype and is often worsened by comorbidities such as obesity, which heighten symptoms and disability. Emotional regulation and eating behaviors are critical areas influencing the progression and management of RRMS. Objective: To assess the feasibility and acceptability of the Unified Protocol, a transdiagnostic treatment, in improving psychological symptoms, emotional regulation, andeating behaviours in Chilean RRMS patients, particularly those living with obesity or overweight. Method: The sample included 7 RRMS patients who underwent 14 sessions of the UP. The UP aims to manage and prevent emotional symptoms by enhancing emotional regulation skills, crucial for reducing future psychological distress such as anxiety and depression. The intervention focused on disrupting the cycle of emotional eating and enhancing overall quality of life. Results: Results showed improvements in emotional regulation and reductions in depression and anxiety. However, these effects diminished overtime, with an increase in emotional eating, underscoring the need for continuous support and targeted strategies. Conclusions: The findings of this pilot study on feasibility and acceptability highlight the potential of the UP in treating RRMS, emphasizing the importance of comprehensive, multidisciplinary approaches and further research into sustained and tailored treatments. This study is an extension of a wider RCT which has already been pre-registered [osf.io/sr4bx].