The growing scarcity of freshwater has accelerated the global deployment of desalination technologies, especially reverse osmosis (RO), as an alternative to meet increasing water demands. However, this process generates substantial quantities of brine-a hypersaline waste stream that can severely impact marine ecosystems if improperly managed. This perspective review explores the use of urease-driven Microbially Induced Carbonate Precipitation (MICP) as a biotechnological solution aligned with circular economy principles for the treatment and valorization of RO brines. Through the enzymatic activity of ureolytic microorganisms, MICP promotes the precipitation of calcium carbonate and other mineral phases, enabling the recovery of valuable elements and reducing environmental burdens. Beyond mineral capture, MICP shows promise in the stabilization of toxic metals and potential integration with microbial electrochemical systems for energy applications. This review summarizes current developments, identifies existing challenges, such as microbial performance in saline conditions and reliance on conventional urea sources, and proposes future directions focused on strain optimization, nutrient recycling, and process scalability for sustainable implementation.