Objective: The objective of this systematic review is to determine whether smoking causes organic dysphonia in adults with chronic obstructive pulmonary disease (COPD). Materials and methods: The review adheres to the PRISMA statement guidelines and involves database selection based on defined key terms. Studies were included or excluded based on specific criteria. The research question was constructed using the PIO model, and the quality of evidence and strength of recommendation were assessed using the GRADE pro GDT system. Results: The review conducted searches in databases such as PUBMED, SPRINGER LINK, SCIENCEDIRECT, SCOPUS, and EBSCO, using variable crosses generated from DESC and MESH keywords. After applying filters, a final sample of 30 articles was used in this research. Smoking-induced changes in laryngeal anatomical structure can lead to functional problems and have a negative impact on voice production, resulting in voice disorders. In individuals with COPD, voice quality is further compromised by disease-related symptoms, leading to reduced and irregular voice quality. Conclusions: Dysphonia is a prevalent finding in adults with COPD, and smoking emerges as one of the primary factors contributing to its occurrence. The review underscores the role of smoking as a causative factor in organic dysphonia among individuals with COPD.