Objective: This systematic review aims to describe the long-term effects of laryngeal tuberculosis on the adult voice. Materials and methods: The review followed the PRISMA statement guidelines and utilized the PIO model for database selection. The quality of evidence was assessed, and recommendations were graded using the GRADE system. Results: The review identified 36 articles meeting the inclusion criteria through keyword searches in the DECS and MESH databases. Laryngeal tuberculosis (LTB) was found to have significant longterm effects on the voice, as the larynx plays a crucial role in sound production and vocal quality. Even after the disease has been treated and cured, voice changes and alterations may persist. The vocal folds were the most affected and frequently mentioned structure leading to changes in voice quality and functionality. Dysphonia emerged as the primary effect of LTB, attributed to alterations in the flexibility and oscillatory function of the vocal folds for voice production. Conclusions: Laryngeal tuberculosis has a lasting impact on the adult voice, primarily affecting the vocal folds and resulting in dysphonia. These findings underscore the importance of early diagnosis and appropriate management to mitigate long-term voice-related consequences in individuals with LTB.