This article interrogates the literary meanings of the contemporary crisis based on the review of an Argentine novel –Noxa (2016) by María Inés Krimer– in which elements linking the crisis with spatiality, understood as a key axis of interpretation, can be observed. Among the main aspects that configure this linkage, we distinguish, firstly, the ecosystemic problem of the territory, derived from extractivist activity and corporate dispossession in marginal spaces and, secondly, the disease as a symptom of a collapsed system, which extends its damage towards the human and planetary body. Based on the above, it seems pertinent to us to pose the following questions: what new emphases of crisis are constructed in the novel? what aesthetic forms allow the staging of a sick territory? what subjects of the crisis are elaborated and under what circumstances do they inhabit these territories? Our hypothesis is that a specific relationship between gender, space and body is elaborated under the eaves of the crisis.