Introduction: evidence-Based Nursing is essential in Primary Health Care, but its implementation in Chile remains limited. Objective: to identify attitudes, knowledge, skills and perceptions of Primary Health Care nurses regarding the use of this tool in their professional practice. Method: concurrent mixed study, with nursing professionals from the Doctor Fernando Monckeberg Family Health Center, a universe of fifteen nurses. The Clinical Effectiveness and Evidence-Based Practice Questionnaire was applied, an ad-hoc instrument with variables such as age, gender, years of professional practice, internet use, training, and English proficiency. Semi-structured interviews were used for qualitative analysis, with prior signing of informed consent. Results: the fourteen participants (93,3 %) were women, mean age 34,5 years, 20 % declared training in Evidence-Based Nursing in the last 2 years, 47 % applied it in their work environment. In the analysis of the Instrument, the total mean was 5,6. The “Attitude” dimension had the highest score, 6,6. The qualitative analysis established four categories, three meta-inferences: Attitudes towards Evidence-Based Nursing and its impact on Practice, Training and Knowledge, Related Skills and Professional Practice. Conclusion: attitudes towards Evidence-Based Nursing are favorable, nurses face practical obstacles that limit its application. Adequate training and nursing leadership are essential to overcome these barriers.