The research presented in the article is dedicated to the analysis of the transformation of the territorial-industrial structure of revenue in the Russian IT sector in 2019–2022. Based on the analysis of data from the “SPARK-Interfax” system, the dynamics of revenue of enterprises in the Russian IT industry is examined in the context of its key industries – software development and activities in the field of information technology. The analysis also considered the computer, electronic and optical products manufacturing industry, which does not belong to the collective grouping of the IT industry, but is part of the collective grouping of the information and communications technology (ICT) sector. Based on the calculations carried out, a general trend towards an increase in the concentration of the economic potential of the IT sector of the Russian Federation in its largest centers, which have the most favorable conditions for its development, has been identified. As part of the study, a classification of regions of Russia specialized in the IT industry with a contribution of more than 0.5 % to the total revenue of the IT sector of the Russian Federation in 2022 is proposed, territorial groups of regions are considered and their key features are described. In relation to the revenue of IT companies in the context of regions of Russia, the Herfindahl-Hirschman index was calculated, reflecting the level of concentration (monopolization) of the IT industry in the regions of Russia. Taking into account the current state and dynamics of the territorial organization of the economic potential of the Russian IT industry, the identified trends in its transformation in the period 2019–2022, expert assessments of further changes in the situation in the area under consideration were made, practice-oriented recommendations were proposed for the development and subsequent implementation of effective state regional policy in areas of development and support of the Russian IT industry.