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Structural Brain Differences in the Alzheimer's Disease Continuum: Insights Into the Heterogeneity From a Large Multisite Neuroimaging Consortium
| Indexado |
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| DOI | 10.1016/J.BPSC.2024.07.019 | ||
| Año | 2024 | ||
| Tipo |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
Background: Neurodegenerative diseases require collaborative, multisite research to comprehensively grasp their complex and diverse pathological progression; however, there is caution in aggregating global data due to data heterogeneity. In the current study, we investigated brain structure across stages of Alzheimer's disease (AD) and how relationships vary across sources of heterogeneity. Methods: Using 6 international datasets (N > 27,000), associations of structural neuroimaging markers were investigated in relation to the AD continuum via meta-analysis. We investigated whether associations varied across elements of magnetic resonance imaging acquisition, study design, and populations. Results: Modest differences in associations were found depending on how data were acquired; however, patterns were similar. Preliminary results suggested that neuroimaging marker–AD relationships differ across ethnic groups. Conclusions: Diversity in data offers unique insights into the neural substrate of AD; however, harmonized processing and transparency of data collection are needed. Global collaborations should embrace the inherent heterogeneity that exists in the data and quantify its contribution to research findings at the meta-analytical stage.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Evans, Tavia E. | - |
Erasmus MC - Países Bajos
|
| 2 | Vilor-Tejedor, Natalia | - |
Erasmus MC - Países Bajos
Pasqual Maragall Foundation - España Centro de Regulacion Genomica, Barcelona - España Hospital del Mar - España |
| 3 | Operto, Gregory | - |
Pasqual Maragall Foundation - España
|
| 4 | Falcon, Carles | - |
Pasqual Maragall Foundation - España
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina - España |
| 5 | Hofman, Albert | - |
Harvard T.H. Chan School of Public Health - Estados Unidos
|
| 6 | Ibáñez, Agustin | - |
Universidad Adolfo Ibáñez - Chile
Consejo Nacional de Investigaciones Científicas y Técnicas - Argentina Trinity College Dublin - Irlanda |
| 7 | Seshadari, Sudha | - |
The University of Texas Health Science Center at San Antonio - Estados Unidos
|
| 8 | Tan, Louis C.S. | - |
National Neuroscience Institute of Singapore - Singapur
USA Parkinson Foundation - Singapur |
| 9 | Weiner, Michael | - |
San Francisco VA Health Care System - Estados Unidos
UCSF School of Medicine - Estados Unidos |
| 10 | Alladi, Suverna | - |
National Institute of Mental Health and Neuro Sciences - India
|
| 11 | Anazodo, Udunna | - |
Institut-Hôpital Neurologique de Montréal - Canadá
|
| 12 | Gispert, Juan Domingo | - |
Pasqual Maragall Foundation - España
|
| 13 | Adams, Hieab H.H. | - |
Erasmus MC - Países Bajos
Universidad Adolfo Ibáñez - Chile |
| Fuente |
|---|
| Consejo Nacional de Investigaciones Científicas y Técnicas |
| Ministerio de Economía y Competitividad |
| Fondo Nacional de Desarrollo Científico y Tecnológico |
| Fogarty International Center |
| National Institutes of Health |
| Fondo de Fomento al Desarrollo Científico y Tecnológico |
| Generalitat de Catalunya |
| Alzheimer's Association |
| Seventh Framework Programme |
| Ministerio de Ciencia, Innovacion y Universidades |
| National Health and Medical Research Council |
| Nederlandse Organisatie voor Wetenschappelijk Onderzoek |
| Agencia Estatal de Investigación |
| Science and Industry Endowment Fund |
| National Institute on Aging |
| U.S. Department of Defense |
| Centro de Excelencia Severo Ochoa |
| Commonwealth Scientific and Industrial Research Organisation |
| ZonMw |
| European Molecular Biology Laboratory |
| National Institute of Biomedical Imaging and Bioengineering |
| Agencia Nacional de Investigación y Desarrollo |
| Cooperative Research Centres, Australian Government Department of Industry |
| ‘la Caixa’ Foundation |
| Edith Cowan University |
| DOD ADNI |
| Alzheimer's Disease Neuroimaging Initiative |
| Rainwater Charitable Foundation |
| PRTR |
| European Union Next Generation EU |
| CARDS-NIH |
| Institute for Mental Health Research |
| National Ageing Research Institute |
| Austin Health |
| CogState Ltd. |
| EU/EFPIA |
| Agradecimiento |
|---|
| NACC: The NACC database is funded by NIA/NIH Grant U24 AG072122. NACC data are contributed by the NIA-funded ADCs: P50 AG005131 (PI James Brewer, MD, PhD), P50 AG005133 (PI Oscar Lopez, MD), P50 AG005134 (PI Bradley Hyman, MD, PhD), P50 AG005136 (PI Thomas Grabowski, MD), P50 AG005138 (PI Mary Sano, PhD), P50 AG005142 (PI Helena Chui, MD), P50 AG005146 (PI Marilyn Albert, PhD), P50 AG005681 (PI John Morris, MD), P30 AG008017 (PI Jeffrey Kaye, MD), P30 AG008051 (PI Thomas Wisniewski, MD), P50 AG008702 (PI Scott Small, MD), P30 AG010124 (PI John Trojanowski, MD, PhD), P30 AG010129 (PI Charles DeCarli, MD), P30 AG010133 (PI Andrew Saykin, PsyD), P30 AG010161 (PI David Bennett, MD), P30 AG012300 (PI Roger Rosenberg, MD), P30 AG013846 (PI Neil Kowall, MD), P30 AG013854 (PI Robert Vassar, PhD), P50 AG016573 (PI Frank LaFerla, PhD), P50 AG016574 (PI Ronald Petersen, MD, PhD), P30 AG019610 (PI Eric Reiman, MD), P50 AG023501 (PI Bruce Miller, MD), P50 AG025688 (PI Allan Levey, MD, PhD), P30 AG028383 (PI Linda Van Eldik, PhD), P50 AG033514 (PI Sanjay Asthana, MD, FRCP), P30 AG035982 (PI Russell Swerdlow, MD), P50 AG047266 (PI Todd Golde, MD, PhD), P50 AG047270 (PI Stephen Strittmatter, MD, PhD), P50 AG047366 (PI Victor Henderson, MD, MS), P30 AG049638 (PI Suzanne Craft, PhD), P30 AG053760 (PI Henry Paulson, MD, PhD), P30 AG066546 (PI Sudha Seshadri, MD), P20 AG068024 (PI Erik Roberson, MD, PhD), P20 AG068053 (PI Marwan Sabbagh, MD), P20 AG068077 (PI Gary Rosenberg, MD), P20 AG068082 (PI Angela Jefferson, PhD), P30 AG072958 (PI Heather Whitson, MD), P30 AG072959 (PI James Leverenz, MD). |
| AIBL: Funding for the study was provided in part by the study partners [Commonwealth Scientific Industrial and research Organization (CSIRO), Edith Cowan University (ECU), Mental Health Research institute (MHRI), National Ageing Research Institute (NARI), Austin Health, CogState Ltd.]. The study also received support from the National Health and Medical Research Council (NHMRC) and the Dementia Collaborative Research Centres program (DCRC2), as well as funding from the Science and Industry Endowment Fund (SIEF) and the Cooperative Research Centre (CRC) for Mental Health, an Australian Government Initiative. |
| TEE is funded by the Alzheimer\u2019s Nederland WE.03-2020-08, NWO grant 19501. NV-T is funded by the Juan de la Cierva Programme (FJC2018-038085-I), Ministerio de Ciencia, Innovaci\u00F3n y Universidades \u2013 Spanish State Research Agency. All CRG authors acknowledge the support of the Spanish Ministry of Science, Innovation, and Universities to the EMBL partnership, the Centro de Excelencia Severo Ochoa, and the CERCA Programme / Generalitat de Catalunya. AI is supported by grants from CONICET; ANID/FONDECYT Regular (1210195 and 1210176 and 1220995); ANID/FONDAP/15150012; ANID/PIA/ANILLOS ACT210096; FONDEF ID20I10152, ID22I10029; ANID/FONDAP 15150012; Takeda CW2680521 and the MULTI-PARTNER CONSORTIUM TO EXPAND DEMENTIA RESEARCH IN LATIN AMERICA [ReDLat, supported by Fogarty International Center (FIC), National Institutes of Health, National Institutes of Aging (R01 AG057234, R01 AG075775, R01 AG21051, CARDS-NIH), Alzheimer's Association (SG-20-725707), Rainwater Charitable Foundation \u2013 The Bluefield project to cure FTD, and Global Brain Health Institute)]. JDG is supported by the Spanish Ministry of Economy and Competitiveness (RYC-2013-13054) and received research support from the EU/EFPIA Innovative Medicines Initiative Joint Undertaking AMYPAD (grant no. 115952) and from Ministerio de Ciencia, Innovaci\u00F3n y Universidades (grant no. RTI2018-102261). HHHA was supported by ZonMW grant number 916.19.151. |
| ADNI: Data collection and sharing for this project was funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904) and DOD ADNI (Department of Defense award number W81XWH-12-2-0012). ADNI is funded by the National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: AbbVie, Alzheimer\u2019s Association; Alzheimer\u2019s Drug Discovery Foundation; Araclon Biotech; BioClinica, Inc.; Biogen; Bristol-Myers Squibb Company; CereSpir, Inc.; Cogstate; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company; EuroImmun; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; Fujirebio; GE Healthcare; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Lumosity; Lundbeck; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; NeuroRx Research; Neurotrack Technologies; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Piramal Imaging; Servier; Takeda Pharmaceutical Company; and Transition Therapeutics. The Canadian Institutes of Health Research is providing funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health ( www.fnih.org ). The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer\u2019s Therapeutic Research Institute at the University of Southern California. ADNI data are disseminated by the Laboratory for Neuro Imaging at the University of Southern California. |
| ALFA: The research leading to these results received funding from \u2018la Caixa\u2019 Foundation (ID 100010434), under agreement LCF/PR/GN17/10300004 and the Alzheimer\u2019s Association, and an international anonymous charity foundation through the TriBEKa Imaging Platform project (TriBEKa-17-519007). |
| WMH-AD : This work was supported by the Global Alzheimer\u2019s Association Interactive Network (GAAIN) initiative of the Alzheimer\u2019s Association (GAAIN-14-244631) and National Institutes of Health grants U54-EB020406 and P41- EB015922. WMH-AD data used in the preparation of this article was obtained from neuGRID platform ( https://neugrid2.eu ) hosted in the HPC center of the IRCCS Centro San Giovanni di Dio Fatebenefratelli funded by the European (FP7/2007-2013 grant agreement no.283562) and National initiatives (RC-2016-2361095; RRC-2017-2364915; RRC-2018-2365796; CCR-2017-23669078; RRC-2019-23669119_001). |
| NACC: The NACC database is funded by NIA/NIH Grant U24 AG072122. NACC data are contributed by the NIA-funded ADCs: P50 AG005131 (PI James Brewer, MD, PhD), P50 AG005133 (PI Oscar Lopez, MD), P50 AG005134 (PI Bradley Hyman, MD, PhD), P50 AG005136 (PI Thomas Grabowski, MD), P50 AG005138 (PI Mary Sano, PhD), P50 AG005142 (PI Helena Chui, MD), P50 AG005146 (PI Marilyn Albert, PhD), P50 AG005681 (PI John Morris, MD), P30 AG008017 (PI Jeffrey Kaye, MD), P30 AG008051 (PI Thomas Wisniewski, MD), P50 AG008702 (PI Scott Small, MD), P30 AG010124 (PI John Trojanowski, MD, PhD), P30 AG010129 (PI Charles DeCarli, MD), P30 AG010133 (PI Andrew Saykin, PsyD), P30 AG010161 (PI David Bennett, MD), P30 AG012300 (PI Roger Rosenberg, MD), P30 AG013846 (PI Neil Kowall, MD), P30 AG013854 (PI Robert Vassar, PhD), P50 AG016573 (PI Frank LaFerla, PhD), P50 AG016574 (PI Ronald Petersen, MD, PhD), P30 AG019610 (PI Eric Reiman, MD), P50 AG023501 (PI Bruce Miller, MD), P50 AG025688 (PI Allan Levey, MD, PhD), P30 AG028383 (PI Linda Van Eldik, PhD), P50 AG033514 (PI Sanjay Asthana, MD, FRCP), P30 AG035982 (PI Russell Swerdlow, MD), P50 AG047266 (PI Todd Golde, MD, PhD), P50 AG047270 (PI Stephen Strittmatter, MD, PhD), P50 AG047366 (PI Victor Henderson, MD, MS), P30 AG049638 (PI Suzanne Craft, PhD), P30 AG053760 (PI Henry Paulson, MD, PhD), P30 AG066546 (PI Sudha Seshadri, MD), P20 AG068024 (PI Erik Roberson, MD, PhD), P20 AG068053 (PI Marwan Sabbagh, MD), P20 AG068077 (PI Gary Rosenberg, MD), P20 AG068082 (PI Angela Jefferson, PhD), P30 AG072958 (PI Heather Whitson, MD), P30 AG072959 (PI James Leverenz, MD). |
