Introduction and objective: The constant practice of physical activity contributes to obtaining adequate values of physical fitness and body composition, which brings benefits to people's health. Even though scientific evidence exposes the health effects of physical activity, the adult population has a low prevalence of exercise due to lack of time, lack of sports venues, factors that increase in university students due to academic demands. One tool that could be useful in removing barriers to not practicing physical activity may be immersive virtual reality, as evidence suggests that it can be a tool that promotes the practice of physical activity, so the objective of this randomized controlled trial protocol is to evaluate the impact of a physical exercise program performed through immersive virtual reality on physical fitness and body composition in a university population. Methodology: An intervention group (n=18) and a control group (n=18) will be randomly selected. The intervention group will execute a physical exercise program through immersive virtual reality for 12 weeks. All participants will be evaluated at the beginning and end of the intervention to determine the effect of the program on physical fitness and body composition. Conclusions: This randomized controlled trial will provide information on the effect of physical exercise through virtual reality on the variables studied.