We present the results of an interdisciplinary study conducted at the Pedernales-5 site, situated in the Salar de Pedernales basin (26°S; 3356 masl), dated from 10,510−10,749 to 11,201−11,612 cal. BP. Unlike other Late Pleistocene and Holocene sites in the Andean Puna, where vicuñas (Vicugna vicugna) were the primary prey, at Pedernales-5, the zooarcheological assemblage consists almost exclusively of flamingo (Phoenicopteridae) and bird remains. Through the analysis of lithic and bone artifacts, archeobotanical remains, pigment composition, and paleoenvironmental data, we propose that the emphasis on flamingo exploitation cannot be solely explained by alimentary consumption but also served cultural and symbolic purposes related to the acquisition of feathers, hides, and bones. The unique archeological context of Pedernales-5 offers a distinctive perspective on human dynamics in the Andean highlands during the Early Holocene.