Dark matter annihilation can have a strong impact on many astrophysical processes in the Universe. In the case of Sommerfeld-enhanced annihilation cross sections, the annihilation rates are enhanced at late times, thus enhancing the potential annihilation signatures. We here calculate the Sommerfeld-enhanced annihilation signatures during the epoch of helium reionization, the epoch where helium becomes fully ionized due to energetic photons. When considering the upper limits on the energy injection from the CMB, we find that the resulting abundance of He++ becomes independent of the dark matter particle mass. The resulting enhancement compared to a standard scenario is thus 1-2 orders of magnitude higher. For realistic scenarios compatible with CMB constraints, there is no significant shift in the epoch of helium reionization, which is completed between redshifts 3 and 4. While it is thus difficult to disentangle dark matter annihilation from astrophysical contributions (active galactic nuclei), a potential detection of dark matter particles and its interactions using the Large Hadron Collider (LHC) would allow one to quantify the dark matter contribution.