Introduction: Cancer-related pain is a common symptom that affects patients' quality of life. Although exercise has shown analgesic effects in non-cancer pain, its specific impact on cancer pain is not clearly established. Given the variability in cancer types and patient conditions, it is essential to investigate how exercise interventions can be integrated into treatments to improve quality of life. Objectives: To evaluate the impact of exercise on cancer-associated pain in different types of cancer and to analyze whether this effect varies according to the stage of intervention. Methodology: A systematic review of randomized clinical trials was carried out on the effectiveness of different types of exercise in reducing cancer pain. 1.116 registries were identified, of which 11 studies were included with 2.419 participants with a mean age of 50.1±11,49 years, covering breast, colon and prostate cancer. Results: Exercise interventions showed significant reductions in pain and fatigue, improving patients' quality of life. Programs that combined aerobic and strength exercise were particularly effective. Conclusions: Integrating exercise into oncological treatment can significantly improve quality of life and pain management in cancer patients, supporting its role as a complement in treatment.